
EU Moves to Review Safeners and Synergists Under New Chemical Regulation
EU proposes review of key safeners and synergists under Regulation 2024/1487, affecting chemical compliance across sectors. Feedback closes 8 July 2025.


Following concerns over health risks, the UK Health and Safety Executive (HSE) has set new maximum residue levels (MRLs) for methidathion, a pesticide no longer approved for use in Great Britain. Effective from May 2025, these MRLs will limit methidathion residues in food to the minimum detectable levels, aligning with recent Codex Alimentarius standards and addressing potential health risks identified by global and domestic health authorities.
Methidathion, an organophosphate pesticide previously used in various agricultural applications, faced regulatory changes after being linked to health concerns. The pesticide was banned in the EU in 2004 and subsequently in Great Britain after Brexit. The Codex Alimentarius Commission formally revoked all methidathion Codex MRLs in December 2023, following the Joint FAO/WHO Meeting on Pesticide Residues (JMPR) findings, which indicated significant health risks.
In line with the UK's commitment to food safety, the HSE conducted an extensive review of methidathion residues in food. The review, performed under Article 12 of GB’s pesticide regulations, involved evaluating updated toxicological data, including the Acceptable Daily Intake (ADI) and Acute Reference Dose (ARfD), both revised by JMPR in 2022. With these benchmarks in place, HSE determined that any presence of methidathion above the limit of quantification (LOQ) posed a potential health risk, leading to the proposal of the lowest feasible MRL for all methidathion residues in food products.
The newly adopted MRLs set methidathion at an LOQ of 0.01 mg/kg for most food categories, with certain challenging matrices, like herbs, assigned a higher default limit. These updated limits comply with international Codex standards, ensuring consistency in food trade and safety standards globally. Notably, the new limits will come into effect on 5 May 2025, allowing food business operators time to comply with these updated regulations.
The tightened methidathion MRLs underscore the UK's commitment to maintaining high food safety standards. The decision to lower methidathion MRLs to near-zero levels reflects the government’s precautionary stance on pesticides linked to acute and chronic toxicity risks. With methidathion now absent from authorised plant protection products in Great Britain, these stringent MRLs are expected to safeguard consumer health and enhance confidence in domestic and imported food products.




EU proposes review of key safeners and synergists under Regulation 2024/1487, affecting chemical compliance across sectors. Feedback closes 8 July 2025.

The EU invites feedback on the updated plant protection product labelling regulation until 3 February 2025. Share your views to shape the final regulation.

UK takes a bold step to safeguard pollinators, moving to ban harmful neonicotinoid pesticides and support sustainable farming practices.
Subscribe to Foresight Weekly and get the latest insights on regulatory changes affecting chemical compliance.
Free forever. Unsubscribe anytime.
Read by professionals at