Aquatic Toxicity

European Medicines Agency (EMA) Hosts Webinar on NAMs in Ecotoxicology – In Silico Approaches for Acute Fish Toxicity

The European Medicines Agency is hosting an Eco-NAMs webinar on 28 May 2026 showcasing in silico methods to replace acute fish toxicity tests in regulatory ecotoxicology. This signals growing regulatory interest in NAM-based ecotoxicity assessments, so R&D and regulatory teams should track how these approaches may shape future environmental risk testing strategies and data expectations.

24 May 2026, 20:33ema.europa.euEuropean UnionNetherlands

ECHA Updates CLH Registry: No New RAC Opinion for Bifenox

In May 2026 ECHA updated its CLH registry entry for the pesticide active substance bifenox to state that no new data justify another RAC opinion and that the existing harmonised CLP classification remains unchanged. This means no additional CLP-driven classification or labelling changes are expected for bifenox from this review, although companies should monitor for any future dossier resubmissions if new toxicological or environmental data emerge.

20 May 2026, 17:55echa.europa.euEuropean Union

ECHA Moves Methyl-1H-Benzotriazole CLH Dossier To Opinion Development Stage

ECHA has advanced the CLH dossier for methyl-1H-benzotriazole and its inorganic salts into the Opinion Development stage, following closure of the public consultation in May 2026. This signals a likely tightening of harmonised classification under CLP, so companies using this corrosion-inhibiting chemistry should prepare for possible new reproductive, acute toxicity, aquatic and PMT/vPvM-driven obligations on labelling, safety data sheets and risk management once a RAC opinion and ATP are adopted.

20 May 2026, 17:55echa.europa.euEuropean Union

ECHA Moves Tebufenpyrad CLH Proposal to Opinion Development Phase

ECHA has moved the Tebufenpyrad harmonised classification proposal under the EU CLP Regulation from public consultation into the Opinion Development phase, with France as dossier submitter and the consultation now closed. If confirmed, the proposed classification would tighten skin sensitisation and repeated-dose toxicity categories, add carcinogenicity and reproductive toxicity, and maintain very high aquatic hazard, signalling potentially stricter labelling and risk controls for plant protection products using this active substance.

20 May 2026, 17:55echa.europa.euEuropean Union

Idaho DEQ Schedules Triennial Review Meeting On Water Quality Standards In Idaho Falls

Idaho’s Department of Environmental Quality has scheduled a 26 May 2026 Triennial Review meeting in Idaho Falls to present its 2026 review of state surface water quality standards and related issue papers on PFAS, aluminum, and 6PPD‑Q. This indicates early regulatory scrutiny of these contaminants in Idaho’s water quality programme and gives dischargers and water utilities an opportunity to understand and influence priorities before any formal criteria or permit limits are proposed.

19 May 2026, 21:09deq.idaho.govUnited States

ATC/EPPA Challenges CLP 25th ATP Classification of C4:C8 and C9 Substituted Diphenylamine Antioxidants

In early 2026, ATC/EPPA submitted new reproductive and aquatic toxicity analyses arguing that ECHA/RAC’s proposed CLP 25th ATP classifications for C4:C8 and C9 substituted diphenylamine antioxidants overstate both reproductive and aquatic hazards. If regulators accept these arguments and downgrade the classifications (for example from Repr. 1B to Category 2 and from Aquatic Chronic 1 to weaker or no aquatic hazard), SDPA-containing lubricants and related products would face significantly reduced labelling, SVHC and downstream risk-management pressure in the EU.

15 May 2026, 17:46circabc.europa.euEuropean Union

ECHA Updates EU CLP Proposal for Acequinocyl With Chronic Aquatic M-Factor

In May 2026, ECHA updated Germany’s CLH proposal for the plant protection active substance acequinocyl under the EU CLP framework, with the proposed classification now including an M-factor of 1000 for both acute and chronic aquatic hazards alongside other severe hazard classes. If this harmonised classification is later adopted into CLP Annex VI, companies placing acequinocyl-based plant protection products on the EU market would need to reassess labelling, safety data sheets, and environmental risk controls to reflect the very high aquatic toxicity classification.

15 May 2026, 14:59echa.europa.euEuropean Union

Scientific Review Finds PFAS Increase Toxicity of Chemical Mixtures in Aquatic Organisms

A 2026 peer-reviewed review in the journal Toxics finds that PFAS can significantly alter the toxicity of co-occurring pesticides, microplastics and metals in aquatic organisms, often producing synergistic effects on oxidative stress, development, reproduction and immune function. For regulators and companies, this evidence reinforces pressure to treat PFAS as a class, assess cumulative mixture risks rather than single-chemical exposures, and anticipate tighter controls on PFAS uses that contribute to aquatic contamination and biodiversity loss.

14 May 2026, 12:27mdpi.comGlobalUnited States

ECHA REACH Compliance Check: Valeraldehyde Moves to Follow-Up Stage

ECHA has moved the EU REACH compliance check for Valeraldehyde into the follow-up phase after the 4 May 2026 deadline for submitting additional mutagenicity and aquatic toxicity data. This indicates that registrants’ dossiers are now under active scrutiny and that any gaps in required in vivo studies or dossier updates could escalate to national enforcement, so companies using or registering Valeraldehyde should verify compliance urgently.

14 May 2026, 09:26echa.europa.euEuropean Union

Great Britain: HSE Issues GB CLP Technical Report On Methyl Isothiocyanate

In April 2026 the UK HSE, acting as the GB CLP Agency, issued an Article 37 technical report concluding that methyl isothiocyanate warrants broader and more stringent classification, including Carc. 2, STOT RE 1, Fatal if inhaled and very high acute and chronic aquatic toxicity (M-factors 10 and 100). If these conclusions are adopted into the GB MCL list, suppliers and users of MITC-based plant protection and biocidal products will need to update labels, safety data sheets and risk controls, while monitoring emerging divergence from the EU RAC position on acute aquatic hazard stringency.

11 May 2026, 19:02hse.gov.ukUnited Kingdom

GB HSE Article 37 Technical Report Proposes GB MCL Classification for Milbemectin

In April 2026 HSE, acting as the GB CLP Agency, published an Article 37 technical report that agrees with the EU RAC opinion and proposes a new GB mandatory classification and labelling entry for the plant protection active substance milbemectin, adding carcinogenicity, reproductive toxicity, STOT SE 1 and severe aquatic hazard classifications. Although the MCL has not yet been adopted, GB suppliers using milbemectin should anticipate more stringent classification and labelling duties and begin assessing portfolio, labelling and risk-management impacts ahead of eventual implementation.

11 May 2026, 19:02hse.gov.ukUnited Kingdom

Great Britain CLP Agency Technical Report Endorses New Classification for Dodine

HSE’s GB CLP Agency has finalised a technical report backing EU RAC’s proposal to give the fungicide dodine stringent carcinogenicity, systemic toxicity and high aquatic hazard classifications under the GB CLP framework. Once these classifications are adopted into the GB mandatory classification and labelling list, manufacturers, formulators and users of dodine-based plant protection products will need to update labels, safety data sheets and risk controls in line with the tighter hazard profile.

11 May 2026, 19:01hse.gov.ukUnited Kingdom

GB CLP Agency Issues Article 37 Technical Report for 8-Methyldecan-2-yl Propionate (CAS 81931-28-4)

In April 2026 the GB CLP Agency published an Article 37 technical report agreeing with the EU RAC opinion to classify 8-methyldecan-2-yl propionate (CAS 81931-28-4) as Aquatic Acute 1 and Aquatic Chronic 1 with M-factor 10. Although the GB mandatory classification has not yet been adopted, this strongly signals that any future GB MCL entry and product classifications using this plant protection active will need to reflect very high aquatic toxicity and strengthened environmental risk controls.

11 May 2026, 19:01hse.gov.ukUnited Kingdom

ECHA Assessment of Regulatory Needs for 2,6-di-tert-butyl-p-cresol (BHT)

ECHA has issued a group Assessment of Regulatory Needs (ARN) for tert‑alkyl hindered phenols and created a dedicated ARN entry for 2,6‑di‑tert‑butyl‑p‑cresol (BHT), identifying it as part of a priority group with potential endocrine‑disrupting, reproductive and PBT/PMT concerns and widespread uses as an antioxidant in fuels, lubricants, plastics, coatings, adhesives and cosmetics. While no binding measure has yet been proposed, ECHA explicitly foresees harmonised classification followed by a REACH restriction if the hazards are confirmed, so companies using BHT at scale should monitor this file closely and consider substitution or risk‑reduction options in affected formulations and articles.

7 May 2026, 20:10echa.europa.euEuropean Union

ECHA Opens CLH Consultation on Metaldehyde (EC 203-600-2, CAS 108-62-3)

ECHA has launched an EU CLP public consultation on a proposed harmonised classification for the substance metaldehyde, open for comments from 4 May to 3 July 2026. The eventual CLH outcome will fix a uniform EU hazard profile for metaldehyde, shaping how manufacturers and downstream users classify, label, and communicate its risks across products and supply chains.

7 May 2026, 07:47echa.europa.euEuropean Union

EU ECHA RAC Adopts Opinion on Harmonised Classification of 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphthyl)ethan-1-one (CAS 1506-02-1)

By late April 2026, ECHA’s Committee for Risk Assessment had adopted and recorded a harmonised classification opinion under the EU CLP framework for 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (CAS 1506-02-1), proposing Repr. 1B, STOT RE 2 and Aquatic Acute/Chronic 1 classifications. This severe hazard profile signals that a stricter EU legal classification may follow, so companies using this substance should monitor the forthcoming CLP Annex VI decision and prepare for potential impacts on labelling, safety data sheets and affected product lines.

3 May 2026, 09:20echa.europa.euEuropean Union

ECHA RAC Adopts Harmonised Classification Opinion for 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (CAS 21145-77-7)

In April 2026 ECHA’s Risk Assessment Committee adopted a CLH opinion proposing harmonised CLP classification of 1-(5,6,7,8-hexamethyl-2-naphthyl)ethan-1-one as Repr. 1B, STOT RE 2, and Aquatic Acute/Chronic 1. If the Commission later confirms this in CLP Annex VI, manufacturers, importers and downstream users of this widely used fragrance ingredient will face tighter labelling duties, risk management and potential sector-specific restrictions across EU consumer and professional products.

3 May 2026, 09:19echa.europa.euEuropean Union

EU RAC Adopts Harmonised Classification Opinion for 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphthyl)ethan-1-one

ECHA’s Committee for Risk Assessment has adopted a harmonised classification opinion for the fragrance substance 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one, proposing category 1B reproductive toxicity, STOT RE 2 and very high acute and chronic aquatic toxicity. If implemented in EU law, this would introduce a binding harmonised classification that tightens labelling, safety data sheets and risk management expectations for all EU manufacturers, importers and downstream users handling this substance.

3 May 2026, 09:19echa.europa.euEuropean Union

EU RAC Adopts Opinion on Aluminium Phosphide Harmonised Classification Under CLP

In March 2026, ECHA’s Risk Assessment Committee adopted its CLH opinion on aluminium phosphide, and the ECHA registry now records the status as Opinion Adopted for this substance. This advances the EU process towards tightening aluminium phosphide’s harmonised acute toxicity classification and ATE values under CLP, signalling likely future label and risk-management changes for biocidal and plant protection uses.

3 May 2026, 09:19echa.europa.euEuropean Union

EU CLP: ECHA Reviewing CLH Proposal for Calcium 3,5-Dioxo-4-(1-Oxopropyl)-Cyclohexanecarboxylate (CAS 127277-53-6)

ECHA is reviewing a CLH proposal under the EU CLP Regulation to classify calcium 3,5-dioxo-4-(1-oxopropyl)-cyclohexanecarboxylate (EC 603-193-5; CAS 127277-53-6) as a skin sensitiser, suspected developmental toxicant and highly toxic to aquatic life, with the dossier currently in the RAC Opinion Development stage. If this classification is endorsed by RAC and implemented in CLP Annex VI, it would tighten labelling and risk management obligations for plant protection products containing this active substance in the EU and could affect product approvals, formulations and downstream agricultural uses.

3 May 2026, 09:19echa.europa.euEuropean Union