Aquatic Toxicity

Great Britain: HSE Issues GB CLP Technical Report On Methyl Isothiocyanate

In April 2026 the UK HSE, acting as the GB CLP Agency, issued an Article 37 technical report concluding that methyl isothiocyanate warrants broader and more stringent classification, including Carc. 2, STOT RE 1, Fatal if inhaled and very high acute and chronic aquatic toxicity (M-factors 10 and 100). If these conclusions are adopted into the GB MCL list, suppliers and users of MITC-based plant protection and biocidal products will need to update labels, safety data sheets and risk controls, while monitoring emerging divergence from the EU RAC position on acute aquatic hazard stringency.

11 May 2026, 19:02hse.gov.ukUnited Kingdom

GB HSE Article 37 Technical Report Proposes GB MCL Classification for Milbemectin

In April 2026 HSE, acting as the GB CLP Agency, published an Article 37 technical report that agrees with the EU RAC opinion and proposes a new GB mandatory classification and labelling entry for the plant protection active substance milbemectin, adding carcinogenicity, reproductive toxicity, STOT SE 1 and severe aquatic hazard classifications. Although the MCL has not yet been adopted, GB suppliers using milbemectin should anticipate more stringent classification and labelling duties and begin assessing portfolio, labelling and risk-management impacts ahead of eventual implementation.

11 May 2026, 19:02hse.gov.ukUnited Kingdom

Great Britain CLP Agency Technical Report Endorses New Classification for Dodine

HSE’s GB CLP Agency has finalised a technical report backing EU RAC’s proposal to give the fungicide dodine stringent carcinogenicity, systemic toxicity and high aquatic hazard classifications under the GB CLP framework. Once these classifications are adopted into the GB mandatory classification and labelling list, manufacturers, formulators and users of dodine-based plant protection products will need to update labels, safety data sheets and risk controls in line with the tighter hazard profile.

11 May 2026, 19:01hse.gov.ukUnited Kingdom

GB CLP Agency Issues Article 37 Technical Report for 8-Methyldecan-2-yl Propionate (CAS 81931-28-4)

In April 2026 the GB CLP Agency published an Article 37 technical report agreeing with the EU RAC opinion to classify 8-methyldecan-2-yl propionate (CAS 81931-28-4) as Aquatic Acute 1 and Aquatic Chronic 1 with M-factor 10. Although the GB mandatory classification has not yet been adopted, this strongly signals that any future GB MCL entry and product classifications using this plant protection active will need to reflect very high aquatic toxicity and strengthened environmental risk controls.

11 May 2026, 19:01hse.gov.ukUnited Kingdom

ECHA Assessment of Regulatory Needs for 2,6-di-tert-butyl-p-cresol (BHT)

ECHA has issued a group Assessment of Regulatory Needs (ARN) for tert‑alkyl hindered phenols and created a dedicated ARN entry for 2,6‑di‑tert‑butyl‑p‑cresol (BHT), identifying it as part of a priority group with potential endocrine‑disrupting, reproductive and PBT/PMT concerns and widespread uses as an antioxidant in fuels, lubricants, plastics, coatings, adhesives and cosmetics. While no binding measure has yet been proposed, ECHA explicitly foresees harmonised classification followed by a REACH restriction if the hazards are confirmed, so companies using BHT at scale should monitor this file closely and consider substitution or risk‑reduction options in affected formulations and articles.

7 May 2026, 20:10echa.europa.euEuropean Union

ECHA Opens CLH Consultation on Metaldehyde (EC 203-600-2, CAS 108-62-3)

ECHA has launched an EU CLP public consultation on a proposed harmonised classification for the substance metaldehyde, open for comments from 4 May to 3 July 2026. The eventual CLH outcome will fix a uniform EU hazard profile for metaldehyde, shaping how manufacturers and downstream users classify, label, and communicate its risks across products and supply chains.

7 May 2026, 07:47echa.europa.euEuropean Union

EU ECHA RAC Adopts Opinion on Harmonised Classification of 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphthyl)ethan-1-one (CAS 1506-02-1)

By late April 2026, ECHA’s Committee for Risk Assessment had adopted and recorded a harmonised classification opinion under the EU CLP framework for 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (CAS 1506-02-1), proposing Repr. 1B, STOT RE 2 and Aquatic Acute/Chronic 1 classifications. This severe hazard profile signals that a stricter EU legal classification may follow, so companies using this substance should monitor the forthcoming CLP Annex VI decision and prepare for potential impacts on labelling, safety data sheets and affected product lines.

3 May 2026, 09:20echa.europa.euEuropean Union

ECHA RAC Adopts Harmonised Classification Opinion for 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one (CAS 21145-77-7)

In April 2026 ECHA’s Risk Assessment Committee adopted a CLH opinion proposing harmonised CLP classification of 1-(5,6,7,8-hexamethyl-2-naphthyl)ethan-1-one as Repr. 1B, STOT RE 2, and Aquatic Acute/Chronic 1. If the Commission later confirms this in CLP Annex VI, manufacturers, importers and downstream users of this widely used fragrance ingredient will face tighter labelling duties, risk management and potential sector-specific restrictions across EU consumer and professional products.

3 May 2026, 09:19echa.europa.euEuropean Union

EU RAC Adopts Harmonised Classification Opinion for 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphthyl)ethan-1-one

ECHA’s Committee for Risk Assessment has adopted a harmonised classification opinion for the fragrance substance 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one, proposing category 1B reproductive toxicity, STOT RE 2 and very high acute and chronic aquatic toxicity. If implemented in EU law, this would introduce a binding harmonised classification that tightens labelling, safety data sheets and risk management expectations for all EU manufacturers, importers and downstream users handling this substance.

3 May 2026, 09:19echa.europa.euEuropean Union

EU RAC Adopts Opinion on Aluminium Phosphide Harmonised Classification Under CLP

In March 2026, ECHA’s Risk Assessment Committee adopted its CLH opinion on aluminium phosphide, and the ECHA registry now records the status as Opinion Adopted for this substance. This advances the EU process towards tightening aluminium phosphide’s harmonised acute toxicity classification and ATE values under CLP, signalling likely future label and risk-management changes for biocidal and plant protection uses.

3 May 2026, 09:19echa.europa.euEuropean Union

EU CLP: ECHA Reviewing CLH Proposal for Calcium 3,5-Dioxo-4-(1-Oxopropyl)-Cyclohexanecarboxylate (CAS 127277-53-6)

ECHA is reviewing a CLH proposal under the EU CLP Regulation to classify calcium 3,5-dioxo-4-(1-oxopropyl)-cyclohexanecarboxylate (EC 603-193-5; CAS 127277-53-6) as a skin sensitiser, suspected developmental toxicant and highly toxic to aquatic life, with the dossier currently in the RAC Opinion Development stage. If this classification is endorsed by RAC and implemented in CLP Annex VI, it would tighten labelling and risk management obligations for plant protection products containing this active substance in the EU and could affect product approvals, formulations and downstream agricultural uses.

3 May 2026, 09:19echa.europa.euEuropean Union

ECHA RAC Adopts CLH Opinion for Cinnamaldehyde (CAS 104-55-2)

In April 2026, the European Chemicals Agency’s Risk Assessment Committee adopted a harmonised classification opinion for cinnamaldehyde, backing broader CLP hazard classes including skin irritation, eye irritation, strong skin sensitisation at a 0.01% specific concentration limit, and acute and chronic aquatic toxicity. This opinion, ahead of a formal CLP Annex VI amendment, signals likely tighter EU classification, labelling and safety data sheet duties for mixtures and products containing cinnamaldehyde, so formulators and downstream users should anticipate reclassification and related risk-management updates.

3 May 2026, 09:18echa.europa.euEuropean UnionNetherlands

ECHA RAC Adopts CLH Opinion for Reaction Products of Ammonium Bromide and Sodium Hypochlorite (Generated In‑Situ)

In March 2026, ECHA’s Risk Assessment Committee adopted a CLH opinion proposing harmonised reproductive and aquatic hazard classification for reaction products of ammonium bromide and sodium hypochlorite (generated in-situ) in the EU. This opinion signals a likely future CLP Annex VI entry, with potential implications for labelling, risk management and biocidal authorisations once the European Commission adopts a corresponding ATP.

3 May 2026, 09:18echa.europa.euEuropean Union

ECHA RAC Adopts Harmonised Classification Opinion for Sodium Chlorite Under CLP

ECHA’s Risk Assessment Committee has adopted an EU harmonised CLP classification opinion for sodium chlorite, assigning multiple severe health and environmental hazard classes based on an extensive CLH dossier and consultation process. If implemented via a future ATP to CLP, this would significantly tighten labelling, packaging and SDS obligations for sodium chlorite products across the EU, requiring early reclassification, inventory review and risk management updates by suppliers and downstream users.

3 May 2026, 09:18echa.europa.euEuropean Union

ECHA Consultation on REACH Testing Proposals for N-cyclohexylbenzothiazole-2-sulfenamide (CAS 95-33-0)

ECHA is consulting on REACH testing proposals for N-cyclohexylbenzothiazole-2-sulfenamide (EC 202-411-2, CAS 95-33-0), covering bioaccumulation, repeated-dose oral toxicity, in vivo genetic toxicity and reproductive toxicity, with comments due by 12 June 2026. The outcome will determine whether new vertebrate studies are required for this substance and structurally related analogues, influencing future hazard data, classification decisions and REACH compliance planning.

3 May 2026, 07:34echa.europa.euEuropean Union

EU REACH: ECHA Testing Proposal Consultation for Triisobutyl Phosphate (Long-Term Fish Toxicity)

ECHA has added Triisobutyl phosphate (EC 204-798-3, CAS 126-71-6) to its REACH testing proposals list and is inviting third-party information on long-term toxicity to fish, with comments due by 12 June 2026. Manufacturers and downstream users relying on this substance should review existing aquatic toxicity data and consider submitting robust studies to influence the assessment and potentially avoid additional vertebrate testing and stricter classification outcomes.

3 May 2026, 07:32echa.europa.euEuropean Union

ECHA Opens REACH Testing Proposal Consultation on Triethoxysilylpropyl Dibenzoyl Resorcinol (Long-Term Fish Toxicity)

On 28 April 2026, ECHA opened a REACH testing-proposal consultation for Triethoxysilylpropyl Dibenzoyl Resorcinol covering long-term fish toxicity, with third-party submissions due by 12 June 2026. This step tightens scrutiny of the substance’s chronic aquatic hazards and gives registrants and users a brief window to submit data that could influence future vertebrate testing and risk assessment expectations.

3 May 2026, 07:32echa.europa.euEuropean Union

ECHA Publishes REACH Testing Proposal for Tall-Oil Pitch

ECHA has opened a REACH testing proposal consultation for Tall‑oil pitch (EC 232‑414‑4; CAS 8016‑81‑7), covering long-term aquatic, repeated-dose oral and reproductive/developmental toxicity endpoints with third-party data due by 12 June 2026. This signals intensified regulatory scrutiny of Tall‑oil pitch under REACH, so companies using or supplying it should quickly assess available study data, engage with the consultation, and anticipate possible future classification or risk-management actions.

3 May 2026, 07:32echa.europa.euEuropean Union

ECHA Invites Information on REACH Testing Proposal for Bis(4-Methylbenzoyl)peroxide – Long-Term Toxicity to Fish

ECHA has opened a REACH consultation on a vertebrate long-term fish toxicity testing proposal for bis(4-methylbenzoyl)peroxide, with information due by 12 June 2026. Registrants and downstream users relying on this substance should assess existing aquatic toxicity data and consider submitting studies or arguments that could influence testing decisions and future regulatory requirements.

3 May 2026, 07:31echa.europa.euEuropean Union

ECHA Invites Information on Long-Term Fish Toxicity Test Proposal for 1,3-Bis(isocyanatomethyl)benzene (CAS 3634-83-1)

ECHA has opened a REACH testing proposal consultation on long-term fish toxicity for 1,3-bis(isocyanatomethyl)benzene, with third-party data due by 12 June 2026. Registrants and other stakeholders should quickly identify any existing studies or read-across arguments that could satisfy this endpoint and avoid unnecessary vertebrate testing while shaping future classification and risk assessment outcomes.

3 May 2026, 07:31echa.europa.euEuropean Union