Slovenia Intends to Propose n-Hexane as a REACH Substance of Very High Concern

What is n-Hexane Used For?

n-Hexane (EC: 203-777-6, CAS: 110-54-3) is a widely used industrial solvent found in multiple applications:

• Industrial solvents – Essential in adhesives, coatings, rubber, and plastics manufacturing.
• Paints and coatings – Found in surface treatments and chemical formulations.
• Automotive industry – Used in lubricants, greases, and hydraulic fluids.
• Pharmaceutical and laboratory use – Applied in scientific research and healthcare.
• Cosmetics and personal care – Present in fragrances, waxes, and beauty products.

With its classification under REACH Article 57(f), businesses using n-hexane may need to reassess formulations, explore alternatives, or adjust compliance strategies.

Health and Environmental Risks

ECHA classifies n-hexane as a highly flammable liquid and vapour, with additional concerns over chronic health effects:

• Neurotoxic properties – Long-term exposure can cause nerve damage.
• Suspected reproductive toxicity – Potential risk to fertility and foetal development.
• Organ damage – Repeated exposure may affect the central nervous system.
• Environmental hazard – Toxic to aquatic life with long-lasting effects.

Businesses across the manufacturing, automotive, and chemical sectors must evaluate workplace exposure limits, ventilation systems, and employee protective measures to comply with potential future restrictions.

What’s Next for Industry Stakeholders?

The formal SVHC proposal submission is scheduled for 4 August 2025, allowing time for stakeholder engagement and consultation. If approved, n-hexane could be added to the Candidate List for Authorisation, restricting its availability and requiring authorisation for continued use. Companies should:

• Review supply chains – Identify dependencies on n-hexane and explore alternatives.
• Assess workplace safety – Ensure compliance with occupational exposure limits (OELs).
• Monitor regulatory updates – Stay informed on the consultation process and potential classification.