Definition
What is Respiratory Toxicity?
Adverse effects on the respiratory system from inhalation exposure — drives workplace exposure limits, respiratory protection requirements, and substance classification.
Adverse effects on the respiratory system from inhalation exposure — drives workplace exposure limits, respiratory protection requirements, and substance classification.
Foresight tracks Respiratory Toxicity developments and surfaces the alerts most likely to matter before they turn into missed deadlines, recalls, or escalation work.
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Current activity
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Latest alerts below
Last updated
20 May 2026, 06:48
Source-backed regulatory and guidance signals tracked by Foresight, with the newest developments first.
Eurocolour Opposes EU STOT RE 1 Classification for Synthetic Amorphous Silica
Eurocolour has issued an April 2026 position paper strongly challenging the EU’s planned STOT RE 1 classification of synthetic amorphous silica under CLP, arguing the RAC opinion rests on weak science and misinterprets particle effects. If regulators maintain this classification and embed it in REACH general risk assessment, companies using silica in cosmetics, pharmaceuticals and other applications could face far‑reaching restrictions, so it is strategically important to track whether CLP classification or an alternative PSLT/OEL approach ultimately prevails.
Germany Comments on RAC Proposal to Classify Synthetic Amorphous Silica as STOT RE1 Under CLP
Germany’s Federal Office for Chemicals has issued detailed comments broadly supporting the proposed STOT RE1 (inhalation) classification of synthetic amorphous silica under the EU CLP Regulation, while challenging how broadly that classification should apply to different mixture types and uses. If the Commission adjusts the 25th ATP text in line with these arguments, SAS manufacturers and downstream users—especially those supplying sprayable powders, creams, gels and dispersions—will need to reassess which products fall within scope of new chronic inhalation toxicity classification and labelling duties.
Expert Review Challenges ECHA RAC STOT RE 1 Proposal for Synthetic Amorphous Silica (SAS)
An independent toxicology review challenges ECHA’s March 2025 RAC opinion proposing a STOT RE 1 inhalation classification for synthetic amorphous silica, arguing that it conflicts with CLP’s intrinsic-property criteria and recent EU case law on titanium dioxide. If regulators revisit the dossier or pivot towards harmonised occupational exposure limits instead, SAS producers and downstream users could face a materially different balance between hazard labelling, workplace controls, and long-term use viability in EU markets.
FEICA Position Paper on Synthetic Amorphous Silica STOT RE 1 Classification — Exemptions Sought for Firmly Enclosed Adhesive and Sealant Mixtures
In April 2026 FEICA, the European adhesives and sealants industry association, published a position paper opposing the proposed STOT RE 1 (inhalation) harmonised classification of synthetic amorphous silica and requesting that firmly enclosed mixtures be exempted. If regulators proceed without such carve-outs, adhesives and sealant formulators across multiple sectors may face significant reformulation, cost, and substitution risks as they try to maintain performance while managing worker exposure concerns.
New Hampshire Senate Tables HB 1544 Scented Products Ban in State Buildings
In May 2026 the New Hampshire Senate tabled HB 1544, a bill that would require fragrance-free cleaning and personal-care products and ban fragrance-dispensing devices in public areas of state-owned or operated buildings. This pause in the bill’s progress removes any immediate compliance obligations but signals rising occupational health and indoor air-quality scrutiny of fragranced products used in government facilities and potentially by contracted service providers.
EU Industry Submission Challenges ECHA RAC STOT RE 1 Classification for Synthetic Amorphous Silica (SAS)
In March 2025, ECHA’s Risk Assessment Committee adopted an opinion recommending a CLP STOT RE 1 inhalation classification for synthetic amorphous silica (SAS), and an EU cosmetics-focused industry submission has now challenged the opinion’s scientific basis, scope and relevance to real-world exposure. If this classification is carried through into a binding CLP update, it could significantly constrain SAS use in cosmetics and related products, forcing difficult reformulation and substitution decisions and heightening the need to align CLP outcomes with the parallel SCCS safety assessment under the EU Cosmetics Regulation.
Illinois SB4045 Would Prohibit Lachrymatory Agents And Require Approval Of Pepper Spray Formulations
Illinois Senate Bill 4045 would ban most uses of tear gas and other lachrymatory agents in Illinois, require state approval of pepper spray formulations, and create new reporting, database, and enforcement mechanisms for chemical irritants. If enacted, this would fundamentally change law enforcement crowd-control options and the state’s pepper spray market, forcing reformulation, new IDPH rulemaking, and heightened liability and data transparency for chemical agent deployments.
EU Extends Approval of Glutaraldehyde for Biocidal Product Types 2, 3, 4, 6, 11 and 12 Until 2029
The EU has extended the approval of glutaraldehyde for multiple biocidal product types until March 2029 to facilitate a detailed renewal evaluation. This extension offers temporary market stability but maintains pressure on manufacturers to prepare for potential substitution requirements and stricter risk management.
Great Britain Adopts SI 2026/378 Updating Pneumoconiosis Workers’ Compensation Lump-Sum Payments
Great Britain has increased lump-sum compensation rates for workers suffering from dust-related occupational diseases, effective April 1, 2026. This adjustment reflects rising industrial disease liabilities and reinforces the financial risks associated with historical and ongoing exposure to hazardous substances like asbestos and silica.
Switzerland Temporarily Authorises Helicovex (HearNPV) For Emergency Maize Pest Control
Switzerland has issued a temporary emergency authorization for the biopesticide Helicovex to manage maize pests through late 2026. This provides essential biological control for agricultural operations but underscores the ongoing regulatory reliance on short-term derogations for crop protection.
US EPA Proposes Extending TSCA Compliance Dates for Perchloroethylene (PCE) and Carbon Tetrachloride (CTC)
The US EPA is proposing to extend TSCA compliance deadlines for perchloroethylene and carbon tetrachloride for non-federal entities until late 2027. This extension provides industrial operators necessary time to implement complex workplace exposure controls and monitoring programs without delaying the long-term phase-down of these substances.
ECHA Invites Comments On REACH Testing Proposal For Vanadium Dioxide (Deadline 08 May 2026)
ECHA has launched a consultation on REACH testing proposals for vanadium dioxide's inhalation and reproductive toxicity endpoints through May 2026. Stakeholders should leverage existing data to mitigate testing costs and anticipate potential hazard reclassifications that could tighten downstream compliance requirements.
ECHA Consults on Repeated-Dose Inhalation Study for Yttrium Oxide (Deadline 08 May 2026)
ECHA has launched a consultation on a testing proposal for yttrium oxide's repeated-dose inhalation toxicity, with a submission deadline of May 8, 2026. This data-gathering phase is a precursor to potential hazard reclassification or new risk management measures that could impact market access and operational safety requirements.
EU / ECHA Consults On Testing Proposal for Vanadium (Repeated-Dose Inhalation Toxicity)
ECHA has opened a consultation on a REACH testing proposal for vanadium inhalation toxicity with a submission deadline of May 8, 2026. Businesses should leverage existing data to influence the testing outcome and mitigate risks associated with potential future hazard reclassifications.
GB FSA/FSS Publish Safety Assessment on Biotin Feed Additive Authorisation Modification (RP2227)
UK food safety authorities issued a positive safety assessment for the renewal and specification update of biotin as a feed additive in March 2026. This confirms continued market access in Great Britain while reinforcing existing worker safety requirements for handling dusty preparations.
US Department of Veterans Affairs Issues PACT Act Report on Treatment of Toxic-Exposure Conditions
The US Department of Veterans Affairs has released a mandated report analyzing health outcomes linked to military toxic exposures including herbicides and burn pit emissions. This data-driven baseline will inform future federal policy on service-connected medical conditions and long-term liability for environmental health impacts.
US Department of Veterans Affairs Issues Biennial Report on Toxicant Exposure at Karshi-Khanabad Air Base (K2)
The US Department of Veterans Affairs has released its 2025 biennial report on toxicant exposure at the K2 air base, finding no elevated health risks despite the presence of background-level depleted uranium. This data will serve as the scientific foundation for upcoming rulemaking to expand disability benefit eligibility for veterans exposed to toxic substances.
Germany (BAuA) Publishes Study On Silica Dust Exposure Thresholds And Spirometric Decline
Germany's BAuA has published new research defining specific exposure thresholds for respirable crystalline silica linked to significant lung function decline. These findings provide a scientific basis for potential tightening of occupational exposure limits and workplace safety standards for silica-intensive industries.
US MSHA Seeks Comment on Extension of Information Collection for Periodic Medical Surveillance Examinations for Coal Miners
The US Mine Safety and Health Administration is seeking public comment on the extension of mandatory medical surveillance reporting requirements for coal miners. While no substantive changes to health standards are proposed, operators should verify data collection processes to ensure continued alignment with federal respiratory health oversight.
Netherlands RIVM Assesses Feasibility of Cohort Study on Occupational Pesticide Exposure
The Dutch RIVM has confirmed the feasibility of a large-scale cohort study to monitor long-term health impacts of occupational pesticide exposure. This initiative signals a shift toward evidence-based worker protection policies that may lead to stricter occupational exposure limits or targeted use restrictions for specific pesticide classes.
These are just a few of the most recent Respiratory Toxicity alerts. Foresight tracks every jurisdiction, every day — and surfaces only what affects your portfolio, with full citations and evidence.
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Definition
Adverse effects on the respiratory system from inhalation exposure — drives workplace exposure limits, respiratory protection requirements, and substance classification.
Industry relevance
Respiratory Toxicity developments can change product scope, supplier expectations, market access, reporting duties, and risk ownership. Foresight tracks the signals early so teams can respond before obligations become urgent.
Foresight tracking
Foresight monitors official sources, extracts structured regulatory intelligence, and maps alerts to a customer's products, substances, markets, and priorities so teams see the relevant signal with source evidence for review.
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