Organ-specific Toxicity

EU ECHA Updates CLH Dossier For N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline (CAS 34432-92-3) With Consultation Comments

In May 2026 ECHA added the compiled consultation comments (RCOM) document for the ongoing CLH proposal to classify N-ethyl-N-[2-[1-(2-methylpropoxy)ethoxy]ethyl]-4-(phenylazo)aniline (CAS 34432-92-3) as a severe human-health hazard under CLP. This confirms strong member state support for harmonised Acute Tox. 4, Skin Sens. 1B, Repr. 1B and STOT RE 2 classifications, signalling likely future tightening of labelling and risk-management duties for fuel markers and related uses once a RAC opinion and legal act are adopted.

20 May 2026, 17:55echa.europa.euEuropean Union

EU RAC Adopts Harmonised Classification Opinion for 1-(5,6,7,8-Tetrahydro-3,5,5,6,8,8-Hexamethyl-2-Naphthyl)ethan-1-one

ECHA’s Committee for Risk Assessment has adopted a harmonised classification opinion for the fragrance substance 1-(5,6,7,8-tetrahydro-3,5,5,6,8,8-hexamethyl-2-naphthyl)ethan-1-one, proposing category 1B reproductive toxicity, STOT RE 2 and very high acute and chronic aquatic toxicity. If implemented in EU law, this would introduce a binding harmonised classification that tightens labelling, safety data sheets and risk management expectations for all EU manufacturers, importers and downstream users handling this substance.

3 May 2026, 09:19echa.europa.euEuropean Union

EU RAC Adopts Opinion on CLP Harmonised Classification of Phenyl(methylethylketoxime)silane

In March 2026 ECHA’s Committee for Risk Assessment adopted its opinion on Germany’s proposal to strengthen the CLP harmonised classification of phenyl(methylethylketoxime)silane, including carcinogenicity and additional target organ toxicity. If the European Commission follows this in a future CLP Annex VI amendment, companies using the substance in the EU will face tighter labelling and risk-management duties and should plan for updated SDS and downstream use controls.

3 May 2026, 09:18echa.europa.euEuropean Union

GB CLP Agency Recommends Updated Classification for Clethodim

In March 2026, the GB CLP Agency issued a technical report recommending stronger mandatory classification and labelling for the herbicide clethodim under the GB CLP Regulation. If adopted, this will add self-reactive and repeated-exposure organ toxicity classes and upgrade clethodim’s aquatic hazard, tightening labelling and risk management obligations for GB formulators and users of products containing this active substance.

22 Apr 2026, 16:50hse.gov.ukUnited Kingdom

GB CLP Article 37 Technical Report: Nitromethane (CAS 75-52-5)

In March 2026 the UK Health and Safety Executive published an Article 37 GB CLP technical report proposing new mandatory classification and labelling for nitromethane, aligned with the 2025 ECHA RAC opinion on EU CLP. If adopted, these Carc. 1B and Repr. 1B classifications would significantly tighten hazard communication and risk management expectations for nitromethane in Great Britain, requiring companies to update labels, safety data sheets, and exposure controls.

22 Apr 2026, 16:50hse.gov.ukUnited Kingdom

GB HSE Issues Technical Report on Updated MCL Classification for 1-Nitropropane

In March 2026 the GB CLP Agency (HSE) published an Article 37 technical report recommending tighter classification elements for 1-nitropropane, including Acute Tox. 3 (inhalation), Acute Tox. 4 (oral) and STOT RE 2 while retaining Flam. Liq. 3. Although the GB MCL entry has not yet been legally updated, chemical manufacturers and users should anticipate these classifications being written into GB CLP in a future MCL list amendment and assess implications for labelling, safety data sheets and worker protection.

22 Apr 2026, 16:49hse.gov.ukUnited Kingdom

ECHA Publishes Compiled CLH Consultation Comments on Butane-1,4-diol

On 13 April 2026 ECHA updated the CLH registry entry for butane‑1,4‑diol to reflect publication of compiled Member State comments on Germany’s proposal to classify the substance as Acute Tox. 4 (oral, H302; ATE 1 350 mg/kg bw) and STOT SE 3 (H336, narcotic effects). The entry now sits in Opinion Development with a legal deadline for RAC opinion adoption on 19 June 2027, signalling that companies using butane‑1,4‑diol should anticipate a possible Annex VI harmonised classification and prepare for stricter hazard communication and risk management.

19 Apr 2026, 14:23echa.europa.euEuropean Union

GB HSE Issues Agency Opinion Proposing GB MCL For 3,5-Dimethylpyrazole

The UK Health and Safety Executive has formally proposed a mandatory classification for 3,5-dimethylpyrazole as a reproductive toxicant and organ-specific toxin. This move will likely trigger UK REACH restrictions on consumer sales and require immediate updates to safety data sheets and workplace risk assessments across multiple industrial sectors.

3 Apr 2026, 18:01hse.gov.ukUnited Kingdom

Great Britain HSE Agency Opinion Proposes GB MCL for Eugenol

The UK Health and Safety Executive has proposed a mandatory classification for eugenol to align Great Britain with EU standards for toxicity and skin sensitisation. This development necessitates updates to safety data sheets and product labels, alongside a review of workplace risk assessments for manufacturers using this common fragrance and biocidal ingredient.

3 Apr 2026, 17:57hse.gov.ukUnited Kingdom

EU / ECHA Publishes Comments Received On CLH Proposal For Brodifacoum

ECHA has released stakeholder comments on the proposed harmonised classification for brodifacoum as the regulatory process moves toward a formal scientific opinion by mid-2027. Businesses should prepare for continued high-hazard classifications and specific concentration limits that will dictate future labelling requirements and market access for rodenticide products.

1 Apr 2026, 19:31echa.europa.euEuropean Union

ECHA Consults On REACH Testing Proposal For Amides, C8-18 (even numbered) And C18-unsatd., N,N-bis(hydroxyethyl)

ECHA has initiated a consultation on REACH testing proposals for specific amides regarding reproductive and developmental toxicity through May 2026. New data generation may lead to hazard reclassifications and stricter regulatory controls for these substances and related chemical categories.

30 Mar 2026, 16:45echa.europa.euEuropean Union

Canada Adds 2-Ethylhexyl 2-Ethylhexanoate to Part 2 of Schedule 1 to CEPA 1999 (SOR/2026-47)

Canada formally designated 2-ethylhexyl 2-ethylhexanoate as a toxic substance under CEPA Schedule 1 effective March 2026. This listing triggers a legal requirement to develop risk management instruments that prioritize pollution prevention, signaling potential future prohibitions or strict use limits for chemical and consumer product manufacturers.

27 Mar 2026, 18:32gazette.gc.caCanada

EU ECHA BPC Adopts Opinion on Approval of Ethanol for Product Type 2 Disinfectants

The ECHA Biocidal Products Committee has recommended the approval of ethanol for small-surface disinfectants, setting strict purity standards and consumer safety requirements. Although ethanol currently avoids exclusion status, ongoing pressure for more stringent hazard classification signals potential future restrictions and the need for long-term formulation planning.

25 Mar 2026, 12:32echa.europa.euEuropean Union

Brazil (Anvisa) Announces Sector Dialogue on Updating IN 28/2018 for Turmeric-Derived Supplements

Brazil is initiating a regulatory update for turmeric-derived supplements to introduce mandatory safety warnings and clarify concentration limits for total curcuminoids. Companies should prepare for stricter labeling mandates and potential reformulation to address hepatotoxicity risks and maintain compliance in the evolving botanical market.

14 Mar 2026, 15:29gov.brBrazil

ECHA Records 06 March 2026 RAC Opinion Date for Sodium Bromate

ECHA's Risk Assessment Committee adopted an opinion in March 2026 supporting a harmonised classification for sodium bromate as a Category 1B carcinogen and mutagen. This development signals upcoming mandatory labelling changes and likely triggers automatic restrictions for consumer products under the REACH and CLP frameworks.

14 Mar 2026, 08:42echa.europa.euEuropean Union

ECHA Article 46 Decision Requiring OECD TG 408 Study for EC 300-340-2

ECHA has mandated a 90-day oral toxicity study for EC 300-340-2 under REACH to investigate endocrine disruption and neurotoxicity concerns by May 2028. Data generated from this study will directly influence future harmonized classification, potential SVHC identification, and subsequent market restrictions for this substance.

12 Mar 2026, 13:41echa.europa.euEuropean UnionSweden

ECHA Registers German CLH Proposal For Cyflufenamid Harmonised Classification

Germany has proposed a harmonised classification for the fungicide Cyflufenamid, introducing new hazards for endocrine disruption and organ toxicity. Formal adoption would trigger mandatory labeling changes and potentially restrict the substance's use under the EU Plant Protection Products Regulation.

12 Mar 2026, 12:36echa.europa.euEuropean UnionGermany

In Vitro Study Finds Repeated PFOA Exposure Impairs Intestinal Barrier Integrity

New scientific evidence demonstrates that repeated low-level PFOA exposure progressively impairs human intestinal barrier integrity and increases systemic absorption. These findings provide a stronger mechanistic basis for stricter global PFAS limits and lower health-based exposure thresholds for consumer products.

12 Mar 2026, 11:13sciencedirect.comEuropean Union

Japan Food Safety Commission Schedules 63rd Mycotoxins Expert Panel Meeting on Ochratoxin A for 18 March 2026

Japan's Food Safety Commission is conducting a formal health risk assessment review for ochratoxin A in March 2026. This technical evaluation is a critical precursor to potential new or revised regulatory limits for mycotoxin contamination in food products.

12 Mar 2026, 07:19fsc.go.jpJapan

Brazil (Anvisa) Issues Pharmacovigilance Alert on Liver Damage Risk from Turmeric Medicines and Supplements

Brazil’s health regulator has issued a safety alert and mandated label warnings for turmeric-based medicines and supplements following reports of liver toxicity. Companies must update product labeling immediately and prepare for potential market restrictions as authorities re-evaluate the safety of concentrated botanical extracts.

11 Mar 2026, 16:47gov.brBrazil