Developmental Toxicity

California OEHHA Convenes DARTIC Meeting on p,pʹ-Bisphenol Hazard Identification (18 June 2026)

California OEHHA has scheduled a 18 June 2026 DARTIC meeting to review an updated proposal for hazard identification materials on a broad group of p,pʹ-bisphenol chemicals under Proposition 65, based on extensive developmental and reproductive toxicity evidence. While no listing decisions will be taken at this stage, the process signals likely 2027 listing consideration for multiple bisphenol analogues, so companies using these chemistries should start mapping relevant substances, uses, and potential exposure pathways in California.

25 May 2026, 15:35oehha.ca.govUnited States

Netherlands (RIVM) Describes New PARC NAMs Project for Regulatory Developmental Immunotoxicity Assessment

RIVM’s publications catalogue now links to an open‑access *Frontiers in Toxicology* review describing a four‑year PARC project (launched May 2025) to modernise **developmental immunotoxicity (DIT)** assessment in European chemicals regulation using **new approach methodologies (NAMs)**.[^1^](https://www.rivm.nl/publicaties/new-approach-methodologies-nams-to-support-regulatory-assessment-of-developmental#:~:text=New%20approach%20methodologies%20(NAMs)%20to%20support%20regulatory%20assessment%20of%20developmental%20immunotoxicity)[^2^](https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1740390/full#:~:text=The%20current%20testing%20strategy%20for%20the%20assessment%20of%20developmental%20immunotoxicity) The project aims to build a human‑relevant DIT knowledge base (including a **Human Immune System Development Map**) and to develop and evaluate NAMs—such as in vitro TDAR assays, advanced HSC/iPSC‑derived immune cell models, and zebrafish/stickleback systems—to support regulatory decisions like screening, prioritisation and read‑across and, over time, reduce reliance on animal testing.[^2^](https://www.frontiersin.org/journals/toxicology/articles/10.3389/ftox.2026.1740390/full#:~:text=This%20project%20comprises%2014%20partner%20institutions) For compliance teams, this is an important **regulatory‑science signal** on how EU authorities and PARC partners expect future DIT assessments to evolve, but it does **not yet change any legal obligations or testing requirements.**

18 May 2026, 15:09rivm.nlNetherlands

ECHA Opens REACH Testing Proposal Consultation For N,N-Dicyclohexylbenzothiazole-2-Sulphenamide (CAS 4979-32-2)

ECHA has opened a REACH testing proposal consultation on N,N-dicyclohexylbenzothiazole-2-sulphenamide (CAS 4979-32-2), seeking data on in vivo genetic and developmental toxicity with comments due by 12 June 2026. The resulting vertebrate studies and third-party evidence could materially influence future hazard classification and risk management for this substance, so EU registrants and downstream users should monitor outcomes and consider contributing relevant information.

3 May 2026, 07:37echa.europa.euEuropean Union

ECHA Testing Proposal Consultation For Reaction Mass of Oxymethylene Dimethyl Ethers (EC 935-340-7)

In late April 2026, ECHA launched a REACH testing proposal consultation for Reaction mass of oxymethylene dimethyl ethers (EC 935-340-7), seeking data on repeated-dose oral and developmental toxicity endpoints. Registrants and downstream users should review available toxicology data and consider submissions by mid-June 2026 to avoid unnecessary vertebrate testing and influence future regulatory decisions on the substance.

3 May 2026, 07:33echa.europa.euEuropean Union

ECHA Publishes REACH Testing Proposal for Tall-Oil Pitch

ECHA has opened a REACH testing proposal consultation for Tall‑oil pitch (EC 232‑414‑4; CAS 8016‑81‑7), covering long-term aquatic, repeated-dose oral and reproductive/developmental toxicity endpoints with third-party data due by 12 June 2026. This signals intensified regulatory scrutiny of Tall‑oil pitch under REACH, so companies using or supplying it should quickly assess available study data, engage with the consultation, and anticipate possible future classification or risk-management actions.

3 May 2026, 07:32echa.europa.euEuropean Union

EU REACH Testing Proposal for N‑tert‑Butylbenzothiazole‑2‑Sulphenamide (CAS 95‑31‑8)

In April 2026, ECHA opened a REACH testing proposal consultation on N-tert-butylbenzothiazole-2-sulphenamide (CAS 95-31-8), seeking vertebrate studies on reproductive and developmental toxicity with comments due by 12 June 2026. Companies manufacturing, importing or using this substance should quickly review existing data and coordinate any submissions, as the outcome may drive new testing requirements and future risk management decisions under REACH.

3 May 2026, 07:32echa.europa.euEuropean Union

ECHA Testing Proposal Consultation: Dodecyl Acrylate (EC 218-463-4, CAS 2156-97-0)

ECHA has opened a REACH testing proposal consultation for Dodecyl acrylate, seeking data on repeated-dose oral and developmental toxicity ahead of a 12 June 2026 deadline. Companies manufacturing, importing, or using this monomer in EU supply chains should review existing vertebrate and alternative data, consider submitting robust studies, and anticipate potential implications for future hazard classification and regulatory requirements.

3 May 2026, 07:31echa.europa.euEuropean Union

ECHA Opens Call for Information on REACH Testing Proposal for Diniobium Pentaoxide

ECHA has opened a REACH testing proposal consultation for Diniobium pentaoxide, seeking third-party data on reproductive and developmental toxicity between late April and mid-June 2026. Companies manufacturing or using this substance should review existing studies, anticipate potential future classification or restriction impacts, and decide whether to submit information before the consultation deadline.

3 May 2026, 07:31echa.europa.euEuropean Union

ECHA Opens Consultation on REACH Testing Proposal for Dichloro(methyl)(vinyl)silane

In April 2026, ECHA opened a REACH testing proposal consultation for dichloro(methyl)(vinyl)silane, seeking existing data on repeated-dose oral and developmental toxicity before approving new vertebrate studies. Registrants and downstream users should review toxicology portfolios now, consider submitting robust studies by 12 June 2026, and prepare for potential future hazard classification or risk-management actions based on ECHA’s assessment.

3 May 2026, 07:31echa.europa.euEuropean Union

ECHA Opens REACH Testing Proposal Consultation for Amides C12-18 N-Hydroxyethyl

ECHA has opened a REACH testing proposal consultation on reproductive and developmental toxicity studies for Amides, C12-18(even-numbered) and C18(unsatd.), N-hydroxyethyl, with stakeholder submissions due by 12 June 2026. The outcome will determine whether new vertebrate tests go ahead and will shape future hazard assessment and regulatory requirements for this surfactant under REACH.

3 May 2026, 07:31echa.europa.euEuropean Union

EU ECHA Seeks Data on Developmental Toxicity Testing Proposal for CAS 68608-66-2

In April 2026 ECHA opened a REACH testing-proposal consultation on a developmental toxicity study in rabbits for Acetic acid, chloro-, sodium salt, reaction products with 4,5-dihydro-2-undecyl-1H-imidazole-1-ethanol and sodium hydroxide (CAS 68608-66-2), inviting third-party data until 12 June 2026. Companies manufacturing or using this substance should review existing developmental toxicity information and consider submitting robust data to avoid or refine additional vertebrate testing and anticipate potential impacts on their REACH registration.

3 May 2026, 07:31echa.europa.euEuropean Union

ECHA Invites Information on REACH Testing Proposal for 1,2-Diaminotoluene, Ethoxylated and Propoxylated (EC 701-499-4)

In April 2026 ECHA opened a REACH testing‑proposal consultation on 1,2‑Diaminotoluene, ethoxylated and propoxylated (EC 701‑499‑4), seeking third‑party data on repeated‑dose and reproductive/developmental toxicity endpoints by 12 June 2026. This signals that additional hazard data may be required for this substance under REACH, so registrants and affected businesses should quickly assess any existing studies they hold and plan for potential impacts on classification and risk management.

3 May 2026, 07:31echa.europa.euEuropean Union

Canada Opens Consultation on Proposed Restrictions for 1-Bromopropane in Consumer Products

In April 2026, Canada issued its final assessment for the Alkyl Halides Group and opened a consultation on a proposed risk management approach to restrict 1‑bromopropane in certain consumer products, with comments due by 24 June 2026. Companies using 1‑bromopropane in cleaning or automotive products should prepare for tighter Canadian controls, assess alternatives, and consider submitting data during the consultation to shape future CEPA regulations.

30 Apr 2026, 05:45canada.caCanada

EU Researchers Evaluate Chlorpyrifos Developmental Toxicity Using NAM-Based Systematic Review

An EU research team has published an open-access systematic review using new approach methodologies to characterise chlorpyrifos’ developmental and neurotoxic effects across human, rodent, avian, and fish models. The work strengthens the mechanistic case behind existing chlorpyrifos restrictions and illustrates how NAM- and AOP-based evidence can be integrated into next-generation regulatory risk assessments for pesticides and related organophosphates.

28 Apr 2026, 17:47link.springer.comNetherlandsEuropean Union

Delaware House Passes HB 259 (HA 1) on Kindergarten Lead Screening Reporting

In April 2026 the Delaware House passed HB 259 with House Amendment 1, advancing a bill that would formalise statewide reporting on kindergarten lead screening and align it with the existing annual childhood lead report. If enacted, this change would strengthen data visibility on childhood lead exposure in Delaware, signalling closer monitoring of lead screening compliance rather than new direct obligations for manufacturers or other private operators.

19 Apr 2026, 17:42legis.delaware.govUnited States

Environmental Research Study Finds Tap-Water-Level PFAS Impair Mouse Embryo Development Across Generations

New peer-reviewed research shows that PFOS, PFOA, and PFHxS at trace levels typical of municipal tap water can irreversibly disrupt mitochondrial function and development in mouse embryos across multiple generations. This strengthens the scientific case for regulators worldwide to revisit PFAS drinking-water standards and invest in advanced filtration technologies to reduce long-term reproductive and public-health risks.

19 Apr 2026, 17:33doi.orgGlobal

China NMPA Announces 2026 Cosmetics Standards Project Plan

China's National Medical Products Administration’s Comprehensive Department has published a 2026 project plan for cosmetics standards, accompanied by an annex listing standardisation projects for colourant general technical requirements, new raw material monographs, toxicology test methods, product standards, analytical methods, and toothpaste standards. The plan does not itself change legal obligations but signals which areas will be targeted for new or revised national cosmetics standards, so manufacturers and importers using the listed ingredients or product types should review the annex and prepare to track forthcoming draft standards, consultations, and implementation dates.

19 Apr 2026, 17:12nmpa.gov.cnChina

Scientific Review Links PFAS Exposure to Fertility and Pregnancy Complications

A new evidence review in F&S Reviews, reported in April 2026, links PFAS exposure with reduced female fertility and serious pregnancy complications including preeclampsia, fetal growth restriction, and preterm birth. These findings are likely to strengthen the case for more aggressive PFAS controls, including greater product transparency and premarket testing for PFAS and GenX alternatives, shaping future chemical risk benchmarks and reproductive-health policy debates.

14 Apr 2026, 13:05managedhealthcareexecutive.comUnited StatesChina

US Researchers Report PFDA Mechanism Disrupting Foetal Craniofacial Development

New mechanistic research has identified a specific biological pathway through which the long-chain PFAS perfluorodecanoic acid (PFDA) causes fetal developmental defects. This evidence provides a stronger toxicological basis for regulators to prioritize PFDA in human health risk assessments and may accelerate stricter hazard classifications for long-chain PFAS.

5 Apr 2026, 05:26pubs.acs.orgUnited States

ECHA Consults on Reproductive and Developmental Toxicity Testing for Ammonium Trivanadium Octaoxide

ECHA is consulting on reproductive and developmental toxicity testing proposals for ammonium trivanadium octaoxide through May 2026. Potential hazard reclassifications following this assessment could impact registration obligations and chemical safety assessments for vanadium-based materials.

30 Mar 2026, 16:55echa.europa.euEuropean Union