CMR Substances

France Submits Harmonised Classification Dossier for Morpholine Under EU CLP

France has submitted a harmonised classification dossier for morpholine under the EU CLP Regulation, adding a proposed Reproductive Toxicity 1B (H360FD) classification alongside its existing flammability, acute toxicity and skin corrosion hazards. If this proposal is adopted, suppliers and downstream users of morpholine and morpholine-containing mixtures in the EU will face stricter classification, labelling and risk-management obligations and may need to reassess substitution and exposure controls.

10 Apr 2026, 12:48echa.europa.euEuropean Union

Great Britain Proposes UK REACH Restriction on Hazardous Substances in Tattoo Inks and Permanent Make-Up

Great Britain has notified a draft UK REACH restriction that would impose strict classification-based and substance-specific concentration limits, plus detailed labelling rules, for hazardous substances in tattoo inks and permanent make-up mixtures, with consultation open until 30 May 2026. For manufacturers, importers and studios supplying the GB market this signals an upcoming need to reformulate against UK REACH/UK CLP and UK Cosmetics thresholds, implement new ingredient and allergen labelling (including nickel and chromium(VI) warnings), and prepare for enforcement once the restriction is adopted.

10 Apr 2026, 11:00members.wto.orgUnited Kingdom

EU / ECHA Opens Call for Evidence on Toluene Occupational Exposure Limits

ECHA has launched a call for evidence on toluene occupational exposure limits (OELs) running until July 1, 2026, to support the development of new binding EU workplace standards. Businesses using toluene should evaluate current exposure levels and provide data to shape future regulatory thresholds that may necessitate enhanced engineering controls or biological monitoring.

8 Apr 2026, 16:02echa.europa.euEuropean Union

ECHA Call for Evidence on Occupational Exposure Limit for Naphthalene

ECHA has launched a call for evidence to establish new EU-wide Occupational Exposure Limits (OELs) for naphthalene, with submissions due by July 1, 2026. Stakeholders should proactively submit exposure and health data to shape future workplace standards that may require significant investments in engineering controls or monitoring.

8 Apr 2026, 16:01echa.europa.euEuropean Union

ECHA Call for Evidence on Bisphenols (BPS, BPF, BPAF) for Occupational Exposure Limits

ECHA has launched a call for evidence on BPS, BPF, and BPAF to evaluate new EU Occupational Exposure Limits (OELs) under the CMRD, closing July 1, 2026. This is a critical window for industry to provide exposure and toxicological data to shape future binding workplace limits and mitigate potential operational risks.

8 Apr 2026, 16:00echa.europa.euEuropean Union

ECHA Call for Evidence on Including Endocrine Disruptors in the CMRD

ECHA has launched a call for evidence to evaluate incorporating endocrine disruptors into the Carcinogens, Mutagens and Reprotoxic Substances Directive (CMRD). Inclusion would likely subject endocrine disruptors to the EU's strictest occupational exposure limits, requiring manufacturers to reassess workplace safety protocols and substance risk profiles.

8 Apr 2026, 15:58echa.europa.euEuropean Union

Great Britain CLP Agency Proposes Repr. 1B Classification for Tincalconite (CAS 12045-88-4)

The GB CLP Agency issued an opinion in March 2026 proposing a new mandatory classification for tincalconite as a Category 1B reproductive toxicant, aligning Great Britain with EU standards. This classification will trigger automatic restrictions on consumer market access under UK REACH and necessitate updates to safety data sheets and workplace risk assessments.

6 Apr 2026, 19:37hse.gov.ukUnited Kingdom

Great Britain HSE Agency Opinion Proposes Repr. 1B GB Mandatory Classification for Ulexite

The UK HSE has proposed a Repr. 1B mandatory classification for ulexite, aligning Great Britain with existing EU harmonised standards. This classification triggers future UK REACH restrictions on consumer supply and necessitates updated workplace safety controls and SDS compliance.

6 Apr 2026, 19:37hse.gov.ukUnited Kingdom

ECHA Starts OEL Dossier Preparation For Bisphenols, Copper, Lithium, Naphthalene And Toluene

ECHA has initiated the preparation of scientific dossiers to establish or update Occupational Exposure Limits (OELs) for bisphenols, copper, lithium, naphthalene, and toluene. Businesses should prepare for potential new binding limit values by reviewing current workplace monitoring data and assessing the feasibility of stricter exposure controls.

6 Apr 2026, 16:10echa.europa.euEuropean Union

ECHA Issues Guidance on REACH Restrictions for Aprotic Solvents NMP, DMF, DMAC and NEP

ECHA has issued updated guidance on REACH Annex XVII restrictions for aprotic solvents (NMP, DMF, DMAC, NEP), clarifying mandatory worker DNELs and compliance deadlines through 2029. Companies must update safety data sheets and workplace risk management measures to align with these harmonized limits to ensure continued regulatory compliance and worker protection.

5 Apr 2026, 05:51echa.europa.euEuropean Union

ECHA Updates Regulatory Needs Assessment For Benzoates, Proposes Compliance Checks For Potassium Benzoate

ECHA updated its Assessment of Regulatory Needs for 25 benzoates, recommending harmonized classification and restrictions for specific high-tonnage esters due to reproductive toxicity concerns. Future regulatory actions are likely to impact professional-use products, cosmetics, and textiles through new labeling requirements and market access restrictions.

5 Apr 2026, 05:38echa.europa.euEuropean Union

Luxembourg Government Proposes New Lead and Diisocyanates Limits in Workplace Chemical Regulations

Luxembourg has proposed a government amendment to transpose Directive (EU) 2024/869, significantly lowering occupational exposure and biological limit values for lead and introducing new limits for diisocyanates. Companies must prepare for stricter monitoring requirements and a phased reduction in permissible blood lead levels, with the most stringent limits taking effect from January 2029.

5 Apr 2026, 05:22cc.luLuxembourg

US FDA Announces Color Additive Petition To Remove Methylene Chloride, Trichloroethylene, and Ethylene Dichloride From Color Additive Regulations

The US FDA is considering a petition to remove methylene chloride, trichloroethylene, and ethylene dichloride as permitted solvents in specific food, drug, and cosmetic color additives. Although the proposal is based on industry abandonment, a final rule would formalize the restriction of these chlorinated solvents, requiring manufacturers to ensure extraction processes remain compliant with revised ingredient standards.

4 Apr 2026, 10:31govinfo.govUnited States

Italy (INAIL) Publishes Guidance on Formaldehyde Exposure in Pathology Laboratories

Italy’s INAIL has issued new guidance on managing formaldehyde exposure in pathology laboratories, reinforcing strict occupational exposure limits and the mandatory hierarchy of prevention. Businesses using formaldehyde must prioritize substitution with safer alternatives and ensure rigorous technical controls to meet the now-fully-effective 0.37 mg/m³ 8-hour limit.

4 Apr 2026, 10:28inail.itItaly

Japan MHLW Amends Designation Criteria For Carcinogenic Substances Under Industrial Safety And Health Ordinance

Japan’s MHLW has clarified the designation criteria for carcinogenic substances under the Industrial Safety and Health Ordinance, effective March 31, 2026. Businesses must verify substance inventories against recent GHS classification updates to ensure accurate risk assessments and workplace safety compliance.

3 Apr 2026, 18:51mhlw.go.jpJapan

GB HSE Issues Agency Opinion Proposing GB MCL For 3,5-Dimethylpyrazole

The UK HSE has proposed a mandatory classification (GB MCL) for 3,5-dimethylpyrazole as a Category 1B reproductive toxicant. This designation will likely trigger UK REACH restrictions on consumer sales and necessitate updated safety data sheets and workplace risk assessments across the paints, coatings, and textile sectors.

3 Apr 2026, 18:01hse.gov.ukUnited Kingdom

GB HSE Agency Opinion Proposes Repr. 1B GB MCL For Colemanite

The UK HSE has proposed a mandatory Repr. 1B (reproductive toxin) classification for colemanite, aligning Great Britain’s hazard standards with the EU. Impacted firms should prepare for mandatory relabeling and stricter workplace controls, while monitoring for subsequent consumer-use restrictions and SVHC listing under UK REACH.

3 Apr 2026, 18:01hse.gov.ukUnited Kingdom

Great Britain HSE Agency Opinion Proposes Carc. 1B GB MCL for EDTMP‑H

The UK HSE has proposed a new mandatory classification for EDTMP-H as a Category 1B carcinogen, aligning Great Britain with existing EU standards. This designation will trigger stricter workplace controls under COSHH and likely lead to future UK REACH restrictions on consumer use and potential SVHC listing.

3 Apr 2026, 18:00hse.gov.ukUnited Kingdom

Great Britain HSE Proposes Carc. 1B GB MCL for EDTMP-CaNa (CAS 85480-89-3)

The UK HSE has proposed a new Carc. 1B mandatory classification for EDTMP-CaNa, a substance widely used in detergents, cosmetics, and industrial coatings. Adoption will likely trigger UK REACH consumer use restrictions and SVHC listing, requiring manufacturers to evaluate substitution strategies and prepare for significant labeling and SDS updates.

3 Apr 2026, 18:00hse.gov.ukUnited Kingdom

Great Britain: HSE Agency Opinion Proposes Carc. 1B GB MCL for EDTMP‑K

The UK HSE has proposed a new mandatory classification of Carc. 1B (May cause cancer) for EDTMP-K under GB CLP. Businesses using this chelating agent in cleaning, construction, or cosmetic products must prepare for mandatory relabelling, SDS updates, and potential future UK REACH restrictions.

3 Apr 2026, 17:59hse.gov.ukUnited Kingdom