Acute Toxicity

EU / ECHA Opens CLP Harmonised Classification Consultation on 2,4,6,8-Tetramethyl-1,3,5,7-Tetraoxacyclooctane

ECHA has opened an EU CLP consultation on the harmonised classification of 2,4,6,8-tetramethyl-1,3,5,7-tetraoxacyclooctane, a plant protection active substance, with comments due by 03 July 2026. If the proposal is accepted, companies using this substance in plant protection products may see changes to Annex VI classification that affect labelling, risk management measures and authorisation conditions across the EU.

8 May 2026, 06:56echa.europa.euEuropean Union

EU Commission Requests SCCS Safety Opinion on Glyoxylic Acid in Hair Straightening Cosmetics

In May 2026 the European Commission asked its Scientific Committee on Consumer Safety to assess whether the cosmetic ingredient glyoxylic acid is safe in hair straightening products, including at concentrations up to 16 percent, following toxicity concerns and a recent call for data. This scientific review under the EU Cosmetics Regulation could lead to future restrictions or conditions on how glyoxylic acid is used in cosmetic formulations, so manufacturers should monitor the SCCS opinion and prepare for possible reformulation needs.

7 May 2026, 07:45health.ec.europa.euEuropean Union

ECHA RAC Adopts Harmonised CLP Classification Opinion for Bis(pentane-2,4-dionato)calcium

ECHA’s CLH registry shows that its Risk Assessment Committee has adopted a harmonised classification opinion for bis(pentane-2,4-dionato)calcium under the EU CLP Regulation, covering acute oral toxicity, serious eye damage and strong skin sensitisation hazards. Although this classification is not yet implemented in Annex VI, companies using this substance in the EU should expect a future ATP and begin aligning internal classification, labelling and worker-protection measures to reflect the forthcoming harmonised hazards.

3 May 2026, 14:43echa.europa.euEuropean Union

EU RAC Adopts Opinion on Aluminium Phosphide Harmonised Classification Under CLP

In March 2026, ECHA’s Risk Assessment Committee adopted its CLH opinion on aluminium phosphide, and the ECHA registry now records the status as Opinion Adopted for this substance. This advances the EU process towards tightening aluminium phosphide’s harmonised acute toxicity classification and ATE values under CLP, signalling likely future label and risk-management changes for biocidal and plant protection uses.

3 May 2026, 09:19echa.europa.euEuropean Union

ECHA RAC Adopts CLH Opinion on Potassium Bromate Under CLP

ECHA’s Committee for Risk Assessment has adopted its opinion on the harmonised classification of potassium bromate under the CLP Regulation, with the CLH registry now showing status "Opinion Adopted" based on a March 2026 opinion and an April 2026 update. This scientific step signals a likely future CLP Annex VI amendment, so EU companies handling potassium bromate should anticipate stricter carcinogenicity, mutagenicity and acute toxicity classification and start preparing for potential labelling, SDS and risk‑management changes once an ATP is proposed.

3 May 2026, 09:18echa.europa.euEuropean UnionGermany

ECHA Publishes CLH Consultation Comments on Inpyrfluxam

ECHA has published compiled stakeholder and Member State comments from the CLH consultation on the active substance inpyrfluxam, highlighting acute toxicity, reproductive toxicity and aquatic hazard discussions. While this does not change the current legal classification, it signals hazard endpoints that regulators may tighten under CLP, so companies using or formulating with inpyrfluxam should monitor the case and prepare for more stringent labelling scenarios.

27 Apr 2026, 18:20echa.europa.euEuropean Union

ECHA Opens CLP Harmonised Classification Consultation For Maleic Acid

From 20 April 2026 ECHA is consulting on a proposal to tighten the harmonised CLP classification of maleic acid, upgrading it from irritant to corrosive to skin and seriously damaging to eyes while confirming acute oral toxicity. If adopted, this will force updates to classifications, labelling, and safety data sheets for maleic acid and its mixtures, with knock-on impacts on packaging, workplace controls, and downstream product portfolios.

24 Apr 2026, 11:57echa.europa.euEuropean Union

EU CLP Intention Updates Proposed Classification for Deltamethrin (α-cyano-3-phenoxybenzyl [1R-[1α(S*),3α]]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate)

Sweden has updated its EU CLP harmonised classification proposal for the pesticide active substance deltamethrin, adding reproductive toxicity, PBT and repeated-exposure target-organ toxicity on top of existing acute toxicity and very high aquatic hazard, with the CLH intention last updated on 17 April 2026 and dossier submission expected by 26 June 2026. If adopted, this strengthened classification would significantly raise labelling and risk-management requirements for plant protection and biocidal products containing deltamethrin across the EU, increasing regulatory pressure to reassess uses, exposure controls and possible substitution options.

23 Apr 2026, 12:39echa.europa.euEuropean Union

ECHA Moves Inpyrfluxam CLH Intention to Opinion Development

ECHA has advanced the CLH intention for inpyrfluxam, a plant protection active substance, into the Opinion Development phase following completion of public consultation in early 2026. This signals that a stringent harmonised acute toxicity and aquatic hazard classification under the CLP Regulation is being prepared, so agrochemical suppliers should anticipate potential label changes and tighter risk management obligations toward the 2027 opinion deadline.

23 Apr 2026, 12:38echa.europa.euEuropean Union

Great Britain HSE Article 37 Technical Report Confirms Acute Oral Toxicity Classification for Flonicamid

In March 2026, the GB CLP Agency (HSE) issued an Article 37 technical report confirming that flonicamid remains classified as Acute Toxicity Category 4 (H302) under UK CLP, with an acute oral toxicity estimate of 880 mg/kg body weight. This signals that any future mandatory GB classification update will align with the existing EU RAC opinion, so companies using flonicamid in plant protection products should not expect a stricter hazard class but should ensure labelling and risk assessments reflect the confirmed ATE value.

22 Apr 2026, 16:50hse.gov.ukUnited Kingdom

GB CLP Article 37 Technical Report: Nitromethane (CAS 75-52-5)

In March 2026 the UK Health and Safety Executive published an Article 37 GB CLP technical report proposing new mandatory classification and labelling for nitromethane, aligned with the 2025 ECHA RAC opinion on EU CLP. If adopted, these Carc. 1B and Repr. 1B classifications would significantly tighten hazard communication and risk management expectations for nitromethane in Great Britain, requiring companies to update labels, safety data sheets, and exposure controls.

22 Apr 2026, 16:50hse.gov.ukUnited Kingdom

GB HSE Issues Technical Report on Updated MCL Classification for 1-Nitropropane

In March 2026 the GB CLP Agency (HSE) published an Article 37 technical report recommending tighter classification elements for 1-nitropropane, including Acute Tox. 3 (inhalation), Acute Tox. 4 (oral) and STOT RE 2 while retaining Flam. Liq. 3. Although the GB MCL entry has not yet been legally updated, chemical manufacturers and users should anticipate these classifications being written into GB CLP in a future MCL list amendment and assess implications for labelling, safety data sheets and worker protection.

22 Apr 2026, 16:49hse.gov.ukUnited Kingdom

Great Britain HSE Agency Opinion Proposes Revised GB MCL for Bronopol (CAS 52-51-7)

In March 2026 the UK Health and Safety Executive issued an Agency Opinion proposing a revised mandatory GB CLP classification for bronopol, aligning Great Britain’s mandatory labelling with the existing EU harmonised classification. Once implemented this will standardise hazard communication and workplace controls for bronopol-containing biocidal, cosmetic, and industrial products in GB and may influence future product approvals, so companies using the substance should prepare to update labels, safety data sheets, and risk assessments when the GB MCL enters into force.

22 Apr 2026, 16:49hse.gov.ukUnited Kingdom

Czech SZPI Confirms Nutrilon PRO Futura Infant Formula Batch Unsafe Due to Cereulide Toxin

The Czech food safety authority has formally classified a Nutrilon PRO Futura infant formula batch as unsafe after confirming that cereulide toxin exposure for newborns exceeds the EFSA acute reference dose, following a targeted risk assessment in March 2026. This recall escalates regulatory scrutiny of infant formula contamination and signals greater market and cross-border enforcement risk for manufacturers and distributors of baby foods across Europe.

21 Apr 2026, 17:44szpi.gov.czCzechia

Illinois SB4045 Would Prohibit Lachrymatory Agents And Require Approval Of Pepper Spray Formulations

Illinois Senate Bill 4045 would ban most uses of tear gas and other lachrymatory agents in Illinois, require state approval of pepper spray formulations, and create new reporting, database, and enforcement mechanisms for chemical irritants. If enacted, this would fundamentally change law enforcement crowd-control options and the state’s pepper spray market, forcing reformulation, new IDPH rulemaking, and heightened liability and data transparency for chemical agent deployments.

21 Apr 2026, 13:42ilga.govUnited States

China NMPA Announces 2026 Cosmetics Standards Project Plan

China's National Medical Products Administration’s Comprehensive Department has published a 2026 project plan for cosmetics standards, accompanied by an annex listing standardisation projects for colourant general technical requirements, new raw material monographs, toxicology test methods, product standards, analytical methods, and toothpaste standards. The plan does not itself change legal obligations but signals which areas will be targeted for new or revised national cosmetics standards, so manufacturers and importers using the listed ingredients or product types should review the annex and prepare to track forthcoming draft standards, consultations, and implementation dates.

19 Apr 2026, 17:12nmpa.gov.cnChina

ECHA Publishes Compiled CLH Consultation Comments on Butane-1,4-diol

On 13 April 2026 ECHA updated the CLH registry entry for butane‑1,4‑diol to reflect publication of compiled Member State comments on Germany’s proposal to classify the substance as Acute Tox. 4 (oral, H302; ATE 1 350 mg/kg bw) and STOT SE 3 (H336, narcotic effects). The entry now sits in Opinion Development with a legal deadline for RAC opinion adoption on 19 June 2027, signalling that companies using butane‑1,4‑diol should anticipate a possible Annex VI harmonised classification and prepare for stricter hazard communication and risk management.

19 Apr 2026, 14:23echa.europa.euEuropean Union

ECHA Receives CLH Submission for (Benzyloxy)Methanol

Austria submitted a formal proposal to ECHA in March 2026 to classify (benzyloxy)methanol as a Category 1B carcinogen and Category 2 mutagen. This classification would trigger stringent restrictions for biocidal products and mandate hazard labeling for downstream mixtures, impacting market access and formulation strategies.

5 Apr 2026, 05:08echa.europa.euEuropean Union

England and Wales: Home Office Issues 2025 to 2026 Grant for Trading Standards Enforcement of Offensive Weapons Act 2019 Corrosive Products Provisions

The UK Home Office has confirmed nearly £1.8 million in funding for Trading Standards to enforce corrosive product sales and delivery restrictions through March 2026. Retailers and logistics providers face heightened risk of test purchases and compliance audits as authorities prioritize age-restricted hazardous substance controls.

4 Apr 2026, 10:56gov.ukUnited Kingdom

GB HSE Issues Agency Opinion Proposing GB MCL For 3,5-Dimethylpyrazole

The UK Health and Safety Executive has formally proposed a mandatory classification for 3,5-dimethylpyrazole as a reproductive toxicant and organ-specific toxin. This move will likely trigger UK REACH restrictions on consumer sales and require immediate updates to safety data sheets and workplace risk assessments across multiple industrial sectors.

3 Apr 2026, 18:01hse.gov.ukUnited Kingdom