
United States
The U.S. Environmental Protection Agency (EPA) has implemented new rules under the Toxic Substances Control Act (TSCA) to address the health risks posed by trichloroethylene (TCE) and perchloroethylene (PCE). Effective December 2024, these regulations include a complete ban on TCE for all consumer and most industrial uses, while phasing out PCE use in dry cleaning over ten years and restricting other uses to highly controlled environments. Both chemicals are associated with severe health risks, including cancer, neurotoxicity, and reproductive harm. The new measures aim to protect public health, with a focus on reducing workplace exposure and ensuring compliance through robust safety protocols. These rules align with President Biden’s Cancer Moonshot initiative and are expected to generate significant health benefits while also requiring industries to transition to safer alternatives. The EPA will host webinars and provide compliance guidance to affected stakeholders, particularly focusing on vulnerable communities and small businesses disproportionately impacted by these regulations.
Published in December 2024. Dates, deadlines and stages may have changed since.
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The U.S. Environmental Protection Agency (EPA) has introduced stringent new rules to manage the risks of trichloroethylene (TCE) and perchloroethylene (PCE) under the Toxic Substances Control Act (TSCA). Announced on 9 December 2024, these regulations aim to eliminate unreasonable risks posed by these cancer-causing chemicals, banning most uses while implementing rigorous workplace controls for limited exemptions.
The EPA's new rules are part of the Biden administration's Cancer Moonshot initiative. TCE and PCE, widely used industrial solvents, are linked to severe health issues, including liver and kidney cancers, neurotoxicity, and reproductive harm. Michal Freedhoff, Assistant Administrator for the EPA’s Office of Chemical Safety and Pollution Prevention, stated:
“It’s simply unacceptable to allow cancer-causing chemicals to be used for things like glue, dry cleaning, or stain removers when safer alternatives exist.”
All uses of TCE, including in consumer products and most industrial applications, will be prohibited within one year. Limited industrial uses will have longer phaseout periods, supported by a mandatory Workplace Chemical Protection Plan (WCPP). The EPA estimates this rule will reduce long-term workplace exposure by 97%.
The rule for PCE bans its use in consumer products and most industrial applications, with a 10-year phaseout for dry cleaning. Critical uses, such as in petrochemical manufacturing and military applications, will continue under strict safety controls.
TCE and PCE are linked to a wide range of health risks, from cancer to developmental toxicity. The new rules are expected to prevent thousands of cases of cancer and other health conditions annually. While the EPA projects monetised benefits of $32.6 million to $84.6 million annually for PCE and $22.9 million to $23.2 million annually for TCE, transitioning to safer alternatives and implementing workplace protections may cost businesses $64.1 million to $102.4 million annually.
To engage stakeholders, the EPA will host webinars and provide compliance guidance. Special provisions address environmental justice, recognising that minority populations disproportionately suffer from exposure due to their representation in industries like dry cleaning.
Official source
epa.govTCE and PCE are linked to serious health conditions, including liver, kidney, and brain cancers, as well as neurotoxicity, reproductive harm, and developmental toxicity. TCE exposure is also associated with immune suppression and fetal heart defects, making it particularly dangerous even in small quantities.
The regulations ban all uses of TCE and most consumer and commercial uses of PCE, with exemptions for critical applications under stringent safety controls. Industries like dry cleaning, automotive repair, and manufacturing must transition to safer alternatives or adopt workplace chemical protection programs to limit exposure.

Dr Steven Brennan
CEO and co-founder of Foresight, and a co-opted member of ECHA's Committee for Socio-economic Analysis. He holds a PhD in chemical engineering.
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