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Regulatory Action Proposed for Amine-Terminated Aliphatic Ethers

REACH
CLP
17
April 2025
•
400
Dr Steven Brennan
ECHA proposes compliance checks and future restrictions for amine-terminated aliphatic ethers. Understand how this affects your regulatory obligations.
Industrial coating
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Summarise this article

ECHA has proposed compliance checks and potential regulatory actions for amine-terminated aliphatic ethers due to their potential health and environmental hazards. Used widely in manufacturing, these substances may soon face restrictions that will impact formulations, safety documentation, and product compliance across the EU.

Why are amine-terminated aliphatic ethers under review by ECHA?

These substances are linked to concerns over reproductive toxicity, endocrine disruption, and environmental persistence. Their widespread industrial and consumer use has prompted proposals for compliance checks and possible restrictions under REACH and CLP regulations.

What should manufacturers do in response to this regulatory update?

Businesses should assess whether these substances are used in their products and prepare for potential regulatory changes. Actions may include updating safety documentation, conducting internal hazard reviews, or seeking safer alternatives.

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The European Chemicals Agency (ECHA) has issued a proposal to assess and potentially restrict amine-terminated aliphatic ethers under EU chemical policy. Published in March 2025, the report outlines concerns related to reproductive toxicity, endocrine disruption, and environmental persistence. These substances are used extensively across manufacturing sectors including adhesives, sealants, coatings, and cosmetics, raising implications for compliance and product formulation across the European value chain.

Amine-Terminated Aliphatic Ethers Flagged for Hazard Review

ECHA’s latest regulatory needs assessment identifies 24 structurally related substances, of which 18 are fully registered under REACH. These substances, which include mono- and poly-ethers terminated with amine and hydroxy groups, are associated with several hazard endpoints: reproductive toxicity, specific target organ toxicity from repeated exposure (STOT RE), endocrine disruption, and persistent, mobile, and toxic or very persistent and very mobile (PMT/vPvM) properties.

The report categorises these substances into five subgroups and outlines preliminary risk findings based on available data. Compliance checks are proposed for 12 substances, and further actions such as harmonised classification and labelling (CLH) or restrictions could follow depending on the confirmed hazards.

Industry Applications and Exposure Pathways

Widespread Use in Formulations and Consumer Products

These chemicals serve multiple roles such as processing aids, catalysts, and binding agents across sectors. They are used in polymer preparations, coatings, adhesives, and personal care products. Several substances are also employed in industrial applications like lubricants, hydraulic fluids, and metal working products.

Due to their functional roles and physicochemical properties, these substances are expected to be released into the environment through widespread professional and consumer use. Four substances may also be present in articles, further extending their exposure pathways.

Potential Restrictions on Professional Use

For substances where reproductive toxicity or endocrine-disrupting effects are confirmed, ECHA suggests that restriction, rather than authorisation, may be the preferred regulatory mechanism. This approach aims to control risks at the point of market placement. Further investigation is also recommended into potential exposure from articles and the need for broader risk management measures under the CLP Regulation.

Next Steps for Industry

Companies manufacturing or using these substances are advised to monitor compliance check outcomes and prepare for possible reclassification or restrictions. Early risk assessment and substitution planning can reduce potential disruptions and ensure continued market access under the evolving EU Chemicals Strategy for Sustainability.

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