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The European Commission has introduced Delegated Regulation (EU) 2024/2564, amending the classification, labelling, and packaging of hazardous substances under the CLP Regulation (EC) No 1272/2008. This update, effective from 1 May 2026, impacts several key chemicals, including copper, silver, multi-walled carbon nanotubes, and glyphosate. The regulation introduces new hazard classifications such as carcinogenicity, reproductive toxicity, and environmental hazards. Companies are urged to adopt the new labelling and packaging standards early to ensure compliance. The changes reflect the EU’s commitment to improving safety standards for human health and the environment.
Published in October 2024. Dates, deadlines and stages may have changed since.
2 min readAI-drafted, expert reviewed

The European Commission issued Delegated Regulation (EU) 2024/2564, amending Regulation (EC) No 1272/2008 concerning the classification, labelling, and packaging of substances and mixtures. This latest update introduces harmonised classifications for several substances and revises the labelling requirements for hazardous chemicals across the EU. The changes, designed to improve health and environmental safety, will come into effect in May 2026.
The new amendment to Regulation (EC) No 1272/2008, also known as the CLP Regulation, adds new substances to the list of hazardous chemicals while updating the classification of others. These updates will become mandatory by 1 May 2026, although businesses are allowed to adopt the new classifications voluntarily before this date.
The regulation includes significant changes to the classification of several chemicals, particularly in areas like acute toxicity, carcinogenicity, and environmental hazards. Some of the key substances affected by the regulation include:
Copper: Now classified under a more generic category concerning specific surface area, affecting the hazard classification of copper in various forms.Multi-walled Carbon Nanotubes: Classified as carcinogenic (Carc. 1B) due to the potential for inhalation risks.Silver (massive, powder, and nano-sized forms): Now includes classifications for reproductive toxicity and long-term environmental hazards.Acetone Oxime: Classified as Carcinogen 1B and also noted for acute toxicity, skin sensitivity, and eye damage.Glyphosate: Updated classification includes new categories for eye damage and chronic aquatic toxicity.
The revised regulation introduces new hazard classifications for substances based on their risks to human health and the environment. These categories include:
Acute toxicityCarcinogenicityReproductive toxicitySkin and eye irritationAquatic toxicity
For example, acetone oxime has been classified as a carcinogen, while formaldehyde is classified for both mutagenicity and carcinogenicity. Hexyl salicylate, commonly found in fragrances, is now listed under reproductive toxicity.
While the updated regulation becomes enforceable by May 2026, companies handling affected substances are encouraged to implement the new classifications as early as possible. This adjustment period allows businesses time to update labelling and packaging in accordance with the new classifications.
Official source
eur-lex.europa.euIn the 2024 update to the EU CLP Regulation, copper (specific surface area > 0.67 mm²/mg) has been classified as Aquatic Acute 1 and Aquatic Chronic 1, signifying its high environmental risk to aquatic life. The substance carries an M-Factor of 10 for acute toxicity and 1 for chronic toxicity, underscoring the potential harm copper can cause in both short-term and long-term exposure.
The 2024 EU CLP Regulation update reclassifies silver in several forms:Silver Massive (particle diameter ≥ 1 mm) is now classified as Repr. 2 (reproductive toxicity) and STOT RE 2 (specific target organ toxicity, repeated exposure, affecting the nervous system).Silver Powder (particle diameter > 100 nm < 1 mm) and Silver Nano (particle diameter > 1 nm ≤ 100 nm) are classified as Repr. 2, STOT RE 2, Aquatic Acute 1, and Aquatic Chronic 1. The M-Factors for environmental impact reach up to 1000 for silver nano, highlighting the significant ecological and reproductive health concerns associated with silver.

Dr Steven Brennan
CEO and co-founder of Foresight, and a co-opted member of ECHA's Committee for Socio-economic Analysis. He holds a PhD in chemical engineering.
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