
EPA Flags Unreasonable Risk from D4 in Industrial and Environmental Use
EPA draft risk evaluation finds octamethylcyclotetrasiloxane (D4) poses significant risks to workers and aquatic life, signalling regulatory change for industry.


The U.S. Environmental Protection Agency (EPA) released a compliance guide for the 2024 methylene chloride risk management rule issued under the Toxic Substances Control Act (TSCA). This compliance guide aims to help industry, workers, and other interested stakeholders understand and comply with the new regulations, which are designed to prevent injuries, long-term illnesses, and deaths.
In April 2024, the EPA finalised a ban on most uses of methylene chloride, a dangerous chemical known to cause liver cancer, lung cancer, breast cancer, brain cancer, cancer of the blood, and cancer of the central nervous system, as well as neurotoxicity, liver harm, and even death. This regulation, which went into effect on 8 July 2024, aims to protect people from health risks while allowing key uses to continue safely under a robust Workplace Chemical Protection Programme (WCPP).
The compliance guide provides detailed information to help entities understand the rule’s requirements and their responsibilities. It includes specifics on:
This guide is essential for entities involved in the manufacture (including import), processing, distribution, use, or disposal of methylene chloride or products containing methylene chloride, including laboratory settings. It also includes special attention to the interests and needs of small businesses.
In addition to the compliance guide, the EPA released a fact sheet in June 2024 that summarises the rule, identifies who is subject to it, and outlines the compliance timelines.
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