News & InsightsNewsletterLegislation Hub

Foresight

Foresight
AboutContactLog in
Book a Demo
Foresight logo
All News & Insights

Harmonised Classification Review for 3,4-Dimethyl-1H-Pyrazole Underway

CLP
17
September 2024
•
400
Dr Steven Brennan
Participate in ECHA’s public consultation on the updated classification of 3,4-dimethyl-1H-pyrazole, focusing on reproductive toxicity.
Fertilizer on plant
Quick prompts

AI Generated

Get to the point quicker with prompts - a smarter way to get the information you need from our articles.

Summarise this article

The European Chemicals Agency (ECHA) has opened a public consultation on the updated classification of 3,4-dimethyl-1H-pyrazole (3,4-DMP). The consultation focuses on reproductive toxicity, following concerns raised about the substance’s effects in relation to its analogue, 3,4-DMPP. Stakeholders are invited to submit comments by 25 September 2024. The feedback will help determine the final harmonised classification and labelling of 3,4-DMP, which is widely used in industrial applications. This consultation could significantly impact industries using the substance.

What are the primary uses of 3,4-dimethyl-1H-pyrazole?

3,4-dimethyl-1H-pyrazole (3,4-DMP) is commonly used in industrial applications, including the production of agrochemicals, pharmaceuticals, and chemical intermediates for various synthetic processes.

What are the potential risks associated with 3,4-dimethyl-1H-pyrazole?

The potential risks include acute toxicity through ingestion, inhalation, and dermal exposure, as well as reproductive toxicity and carcinogenicity. These risks are being assessed in the public consultation to ensure proper classification and labelling for safety.

AI Assistant

This feature and much more is available on our platform. If you would like early access, please leave your email and we'll get in touch.

We'll be in touch when the Assistant is ready.
Oops! Something went wrong while submitting the form.
Mountains

The European Chemicals Agency (ECHA) has launched a public consultation as part of its harmonised classification and labelling (CLH) process for 3,4-dimethyl-1H-pyrazole (3,4-DMP), a chemical substance commonly used in various industrial applications. This consultation seeks to gather further insights on the reproductive toxicity of the substance, particularly in relation to its analogue, 3,4-dimethyl-1H-pyrazol-1-ium dihydrogen phosphate (3,4-DMPP). The consultation is open until 25 September 2024.

Background on the Substance

The current classification of 3,4-DMP in Annex VI of the Classification, Labelling and Packaging (CLP) Regulation includes:

  • Acute Toxicity Category 4 (Oral): H302
  • Serious Eye Damage Category 1: H318
  • Aquatic Chronic Toxicity Category 3: H412

Belgium, the dossier submitter, has proposed expanding this classification to include additional hazards, such as Acute Dermal and Inhalation Toxicity (H312, H332), Carcinogenicity (H351), Reproductive Toxicity (H361f), and Specific Target Organ Toxicity (H373). These proposed changes aim to ensure the safe use and handling of the substance by industrial operators.

Focus of the Current Consultation

During the RAC-70 CLH working group meeting in July 2024, experts highlighted significant similarities between 3,4-DMP and its analogue, 3,4-DMPP. Notably, reproductive toxicity studies conducted on 3,4-DMP involved relatively low doses, which may have skewed the findings. The working group expressed concerns that the absence of observed maternal toxicity in these studies could be due to insufficient exposure levels, especially considering the higher doses used in 3,4-DMPP studies, where adverse effects were reported.

This consultation invites stakeholders to comment on the proposed read-across justification between the two substances. The data collected will play a pivotal role in determining the final classification of 3,4-DMP.

How to Participate

Stakeholders, including manufacturers, downstream users, and the scientific community, are encouraged to provide comments on the reproductive toxicity data and other scientific evidence relevant to the classification of 3,4-DMP. The consultation is accessible through the ECHA’s website and closes at 23:59 Helsinki time on 25 September 2024.

Conclusion

The outcome of this consultation could have far-reaching implications for industries utilising 3,4-DMP. By participating, stakeholders can help shape the regulatory landscape, ensuring that safety measures are adequately aligned with the latest scientific data.

Read the source story

Read this article now for free!

You have read 3 articles.
Create a free account
or
Log in
to finish reading this article now.

Subscribe to our weekly digest

Sign up to receive our newsletter every Tuesday and get access to all of our content.

By creating an account, you agree to the Terms of Service and Privacy Policy.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
This is some text inside of a div block.

Trusted by professionals at

Dupont
ECHA - European Chemicals Agency
Energizer
Chemours
This is some text inside of a div block.

Get Foresight Today

Stay compliant, reduce risk, and protect your business with our AI-powered chemical policy monitoring—tailored just for you.

Global monitoring of 1,200+ sources
Expert-reviewed, trusted regulatory alerts
Instant risk identification for 350k+ substances

Ready to supercharge your policy monitoring workflow?

We’ll be in touch soon with more details and support to help you get started.
Oops! Something went wrong while submitting the form.
Share with a friend
Copy link

Related Articles

Industrial coatingRegulatory Action Proposed for Amine-Terminated Aliphatic Ethers

April 17, 2025

SpacecraftEU Advances PFAS Restriction and Chemical Reclassification

April 17, 2025

Semiconductor manufacturingEU Assesses Regulatory Needs for Fluorinated Aliphatic Hydrocarbons

March 3, 2025

Foresight regulatory experts
Streamline your chemical compliance
Easy-to-use product compliance management for small and mid-sized manufacturers — mitigate risk and protect market access.
Get started
Subscribe to Foresight's newsletter
Stay ahead with the latest news & insights
Join 1,000s of compliance professionals getting the latest insights right to their inbox for free, every Tuesday.
100% free. No spam. Unsubscribe any time.
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
Stay ahead with the latest news & insights
Subscribe to our free weekly newsletter covering news, events, and expert insights.

Related articles

Industrial coating

Regulatory Action Proposed for Amine-Terminated Aliphatic Ethers

ECHA proposes compliance checks and future restrictions for amine-terminated aliphatic ethers. Understand how this affects your regulatory obligations.

17

Apr 2025

REACH
CLP
Spacecraft

EU Advances PFAS Restriction and Chemical Reclassification

Upcoming PFAS restrictions and chemical reclassifications will impact manufacturing, transport, energy, medical devices, and electronics sectors.

17

Apr 2025

REACH
CLP
Semiconductor manufacturing

EU Assesses Regulatory Needs for Fluorinated Aliphatic Hydrocarbons

The EU has assessed the regulatory needs for fluorinated aliphatic hydrocarbons. While no new restrictions are proposed, manufacturers should monitor potential future policy shifts.

3

Mar 2025

REACH
CLP
Foresight
Providing critical insights, analysis, and guidance to help businesses anticipate changes, make informed decisions, and stay ahead.
News & Insights
Newsletter
Legislation Hub
Coverage
Contact
About
© 2025 Foresight. All rights reserved.
SitemapTerms of servicePrivacy policyCookie policy