EU Reviews Benzophenone-2 and Benzophenone-5 Safety Amid Endocrine Disruptor Concerns

Benzophenone-2 Raises Significant Regulatory Red Flags

Benzophenone-2 (CAS 131-55-5, EC 205-028-9), a UV filter and fragrance ingredient, has been flagged for its potential endocrine activity. The SCCS noted the compound shows clear oestrogenic activity in vitro and in vivo. Concerns also stem from incomplete toxicological data, particularly around genotoxicity, reproductive effects, and long-term exposure.

Due to these unresolved safety questions, the SCCS has not confirmed the compound’s safety for use in cosmetics. This development could initiate further regulatory restrictions under Regulation (EC) No. 1223/2009, prompting stakeholders to begin exploring alternatives or reformulation strategies to avoid future non-compliance.

Benzophenone-5 Deemed Safe Within Current Use Limits

Conversely, Benzophenone-5 (CAS 6628-37-1, EC 613-918-7), currently allowed as a UV filter up to 5% concentration, has been assessed as safe by the SCCS. Its evaluation was supported by a read-across approach using data from Benzophenone-4, a close structural analogue. Given its high water solubility and rapid systemic clearance, BP-5 poses less toxicological concern at authorised levels in cosmetics such as sunscreens and face creams.

The deadline for public comments is 17 June 2025, offering industry stakeholders a critical window to contribute data or feedback that could influence final regulatory decisions.