EU Releases Key Update on PFHxA and PFHpA Evaluation

Overview of the PFHxA and PFHpA Evaluation

The recent publication focuses on the comprehensive assessment of PFHxA and PFHpA, degradation products of a mixed phosphate compound (EC 700-161-3). The evaluation confirms that both substances exhibit Persistent, Bioaccumulative, and Toxic (PBT) as well as very Persistent and very Bioaccumulative (vPvB) characteristics. These classifications position PFHxA and PFHpA as Substances of Very High Concern (SVHC), necessitating closer scrutiny and potential regulatory actions to mitigate their environmental and health impacts.

Key Findings of the Evaluation

Persistence and Bioaccumulation Risks

The evaluation underscores the extreme persistence of PFHxA and PFHpA in environmental compartments such as water, soil, and living organisms. Studies indicate that these substances resist degradation, leading to long-term accumulation in ecosystems. PFHxA and PFHpA have been detected in remote areas like the Arctic and Antarctic, reflecting their ability to undergo long-range transport and bioaccumulation in wildlife and humans.

Toxicological Concerns

PFHxA and PFHpA have been linked to adverse health effects, including liver damage and endocrine disruption. The assessment highlights evidence from both in vitro and in vivo studies demonstrating their potential to interfere with thyroid hormone regulation and other critical biological processes. These toxicological profiles reinforce the need for stringent regulatory measures to control their use and release.

Future Regulatory Outlook

ECHA’s update is part of a broader initiative to address the pervasive challenges posed by PFASs. The ongoing evaluation process, supported by scientific research and stakeholder input, aims to establish a robust regulatory framework that effectively manages the risks of these substances. Industry professionals should monitor publications and participate in consultations to influence and stay ahead of policy changes.