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EPA Designates Five High-Priority Chemicals and Initiates Review for Five More Under TSCA

TSCA
19
December 2024
•
350
Dr Steven Brennan
On 18 December 2024, the EPA designated five High-Priority chemicals for risk evaluation under TSCA and initiated review of five others.
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The EPA has designated acetaldehyde, acrylonitrile, benzenamine, vinyl chloride, and MBOCA as High-Priority Substances for risk evaluation under TSCA. Simultaneously, it initiated a 12-month prioritisation process for benzene, ethylbenzene, naphthalene, styrene, and 4-tert-octylphenol, aiming to assess and mitigate risks associated with these chemicals.

What does it mean when a chemical is designated as a High-Priority Substance under TSCA?

A High-Priority designation means the EPA has identified a chemical as potentially posing unreasonable risks to health or the environment and will conduct a detailed risk evaluation to determine necessary regulatory actions.

How can the public participate in the EPA’s chemical prioritisation process?

The EPA provides a 90-day public comment period during the prioritisation phase, allowing stakeholders to submit information on chemical uses, hazards, and exposure risks. These inputs inform the agency’s final designations.

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On 18 December 2024, the U.S. Environmental Protection Agency (EPA) finalised the designation of five chemicals as High-Priority Substances under the Toxic Substances Control Act (TSCA) and began the yearlong prioritisation process for five additional chemicals. These actions underscore the EPA's commitment to identifying and addressing chemical risks to protect human health and the environment.

High-Priority Substances Designated

The EPA designated five chemicals—acetaldehyde, acrylonitrile, benzenamine, vinyl chloride, and 4,4’-methylene bis(2-chloroaniline) (MBOCA)—as High-Priority Substances for risk evaluation. This marks the conclusion of a 9–12 month prioritisation process.

  • Acetaldehyde (CASRN 75-07-0): Used in adhesives and petrochemicals, it is a probable human carcinogen linked to respiratory system irritation.
  • Acrylonitrile (CASRN 107-13-1): Found in plastics and paints, this chemical is a probable carcinogen associated with respiratory irritation.
  • Benzenamine (CASRN 62-53-3): Used in dyes and resins, it poses risks such as reproductive and blood-related health effects and is a probable carcinogen.
  • Vinyl Chloride (CASRN 75-01-4): Widely used in manufacturing polyvinyl chloride (PVC), vinyl chloride is a known human carcinogen and linked to liver toxicity.
  • 4,4’-Methylene bis(2-chloroaniline) (CASRN 101-14-4): Primarily used in plastics and resins, this probable carcinogen is associated with genetic damage and other adverse health effects​​.

The EPA will now evaluate whether these chemicals present an unreasonable risk to health or the environment under their conditions of use. Risk evaluations exclude cost considerations and focus solely on scientific assessments. If risks are identified, regulatory measures will follow.

New Prioritisation Process for Additional Chemicals

In parallel, the EPA initiated the prioritisation process for five new chemicals: benzene, ethylbenzene, naphthalene, styrene, and 4-tert-octylphenol. This process will span 12 months, during which the EPA will gather data and accept public input to determine whether these chemicals warrant High-Priority designations in December 2025.

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