EU Reopens Glyphosate Carcinogenicity Review, Triggering Regulatory Reassessment

New Evidence Spurs Review of Glyphosate Risks

On 26 June 2025, ECHA formally requested its Committee for Risk Assessment (RAC) to reassess its 2022 opinion on glyphosate’s classification. The review follows a June 2025 study published in Environmental Health by the Ramazzini Institute, which reported potential carcinogenic effects from long-term glyphosate exposure in laboratory animals.

Glyphosate, chemically known as N-(phosphonomethyl)glycine, is a widely used herbicide (EC: 213-997-4; CAS: 1071-83-6) in agricultural, industrial, and domestic applications. The substance is currently classified in the EU as causing serious eye damage and posing chronic aquatic toxicity, but not as carcinogenic.

This reassessment could lead to regulatory reclassification, altering obligations under REACH (Regulation (EC) No 1907/2006).

Implications for Industry and Compliance

The Commission has instructed ECHA to obtain raw data from the Ramazzini Institute’s “Global Glyphosate Study,” which will underpin the new RAC evaluation. Upon receipt, RAC will have 15 months to issue an updated opinion.

Any change in glyphosate’s classification could trigger wide-reaching consequences, including reformulation of products, revised labelling, worker safety protocols, and potential market restrictions. This would affect not only chemical manufacturers but also stakeholders in agriculture, food production, and logistics.

For compliance teams, this development warrants close monitoring. A shift in classification could reframe glyphosate as a substance of very high concern (SVHC), escalating authorisation requirements and regulatory costs.